<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-0099</journal-id>
<journal-title><![CDATA[Cirujano general]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. gen]]></abbrev-journal-title>
<issn>1405-0099</issn>
<publisher>
<publisher-name><![CDATA[Asociación Mexicana de Cirugía General A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-00992021000300193</article-id>
<article-id pub-id-type="doi">10.35366/108573</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Nesidioblastosis del adulto, una entidad poco frecuente para el cirujano general]]></article-title>
<article-title xml:lang="en"><![CDATA[Nesidioblastosis of the adult, a rare entity for the general surgeon]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Myers Esmenjaud]]></surname>
<given-names><![CDATA[Jorge Andrés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Urbina de la Vega]]></surname>
<given-names><![CDATA[José Felipe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mejía Nogales]]></surname>
<given-names><![CDATA[Ramiro Esteban]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López Ortiz]]></surname>
<given-names><![CDATA[Armando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gallegos Garza]]></surname>
<given-names><![CDATA[Adriana Cecilia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Chavira]]></surname>
<given-names><![CDATA[Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez de la Garma]]></surname>
<given-names><![CDATA[Constanza]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Ángeles Pedregal Servicio de Cirugía General ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Ángeles Pedregal Servicio de Radiología e Imagen ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Ángeles Pedregal Servicio de Anatomía Patológica ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Ángeles Pedregal  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2021</year>
</pub-date>
<volume>43</volume>
<numero>3</numero>
<fpage>193</fpage>
<lpage>197</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-00992021000300193&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-00992021000300193&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-00992021000300193&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La nesidioblastosis es una patología del páncreas endocrino poco frecuente que origina cuadros de hipoglucemia por hiperinsulinismo endógeno. Se trata de una hiperplasia de los islotes de Langerhans con una hipertrofia de las células &#946;. Las opciones de tratamiento en la mayoría de los casos es la pancreatectomía distal. Hombre de 64 años que presenta múltiples eventos de hipoglucemia de larga evolución. Se realizó protocolo diagnóstico evidenciándose la presencia sugestiva relacionada con insulinoma. Se decide realizar pancreatectomía distal por laparoscopia. Se informó de un fragmento pancreático con hiperplasia de islotes pancreáticos y células endócrinas aisladas. En la inmunohistoquímica con positividad para sinaptofisina y cromogranina que confirma el diagnóstico de nesidioblastosis difusa. El paciente fue egresado sin complicaciones y con adecuado control metabólico y sin episodios de hipoglucemia. Es así como la nesidioblastosis representa un reto diagnóstico en el paciente con hipoglucemia hiperinsulinémica refractaria a manejo médico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Nesidioblastosis is a rare pathology of the endocrine pancreas that causes hypoglycemia due to endogenous hyperinsulinism. It is a hyperplasia of the islets of Langerhans with a hypertrophy of the &#946;eta cells. Treatment options in most cases are distal pancreatectomy. A 64-year-old male with multiple long-term hypoglycemic events. A diagnostic protocol was performed, evidencing the suggestive presence related to insulinoma. It is decided to perform distal pancreatectomy by laparoscopy. A pancreatic fragment with pancreatic islet hyperplasia and isolated endocrine cells was reported. In immunohistochemistry with positivity for synaptophysin and chromogranin confirming the diagnosis of diffuse nesidioblastosis. The patient was discharged without complications and with adequate metabolic control and without episodes of hypoglycemia. This is how nesidioblastosis represents a diagnostic challenge in the patient with hyper insulinemic hypoglycemia refractory to medical management.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Nesidioblastosis]]></kwd>
<kwd lng="es"><![CDATA[hipoglucemia]]></kwd>
<kwd lng="es"><![CDATA[pancreatectomía distal]]></kwd>
<kwd lng="es"><![CDATA[laparoscopia]]></kwd>
<kwd lng="es"><![CDATA[hiperinsulinismo]]></kwd>
<kwd lng="es"><![CDATA[insulinoma]]></kwd>
<kwd lng="en"><![CDATA[Nesidioblastosis]]></kwd>
<kwd lng="en"><![CDATA[hypoglycemia]]></kwd>
<kwd lng="en"><![CDATA[laparoscopy]]></kwd>
<kwd lng="en"><![CDATA[distal pancreatectomy]]></kwd>
<kwd lng="en"><![CDATA[hyperinsulinism]]></kwd>
<kwd lng="en"><![CDATA[insulinoma]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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