<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412021001000832</article-id>
<article-id pub-id-type="doi">10.24245/gom.v89i10.5253</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Diagnóstico de leucemia mieloide aguda durante el embarazo. Reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Acute myeloid leukemia diagnosed during pregnancy. Case report.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pineda-Mateo]]></surname>
<given-names><![CDATA[María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Pérez]]></surname>
<given-names><![CDATA[Alba]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojo-Novo]]></surname>
<given-names><![CDATA[Sara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario Virgen Macarena Unidad de Gestión Clínica de Obstetricia y Ginecología ]]></institution>
<addr-line><![CDATA[Sevilla ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>89</volume>
<numero>10</numero>
<fpage>832</fpage>
<lpage>838</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412021001000832&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412021001000832&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412021001000832&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  ANTECEDENTES: La leucemia mieloide aguda es el cuarto cáncer diagnosticado con más frecuencia durante el embarazo. En la actualidad, su tratamiento en las distintas etapas del embarazo sigue suponiendo un desafío diagnóstico y terapéutico para los obstetras, oncólogos y hematólogos.  OBJETIVO: Reportar el caso clínico de una paciente embarazada a quien se diagnosticó leucemia mieloide aguda en el primer trimestre, el seguimiento efectuado y el tratamiento propuesto. Además, se revisa la bibliografía existente en relación con este cáncer.  CASO CLÍNICO: Paciente de 33 años, embarazada, con 12 + 5 semanas de amenorrea. Se envió al servicio de Hematología debido al hallazgo de pancitopenia en los estudios de laboratorio del primer trimestre. Enseguida de completar el estudio y tomar una biopsia de médula ósea, se estableció el diagnóstico de leucemia mieloblástica aguda NMP1 y FLT-3 negativos, con 20% de blastos. El embarazo finalizó sin contratiempos a las 15 semanas, mediante interrupción voluntaria, luego de recibir información del diagnóstico, pronóstico y riesgo de teratogenia del tratamiento. En la actualidad, la paciente permanece en lista de espera para trasplante de médula ósea histocompatible.  CONCLUSIONES: La correcta atención al control de los análisis de laboratorio, propios del embarazo, puede permitir un diagnóstico temprano que permita iniciar un tratamiento inmediato, decisivo para el pronóstico. Todo esto, además de la atención y asesoramiento multidisciplinario, resulta esencial para asegurar el bienestar de la madre y del feto.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKGROUND: Acute myeloid leukemia is the fourth most frequently cancer in association with pregnancy. Nowadays, clinical management of AML occurring during pregnancy is a diagnostic and therapeutic challenging.  OBJECTIVE: To report the unpublished case of pregnant diagnosed with acute myeloid leukemia in the first trimester of pregnancy, as well as the follow-up carried out and the proposed treatment. We also review the existing literature in relation to this entity.  CLINICAL CASE: 33-year-old patient, at 12+5 weeks of pregnancy. She was admitted to the hematology service due to the discovery of pancytopenia in the laboratory tests performed in the first trimester. After completing the study and performing a bone marrow biopsy, the patient was diagnosed with NMP1 and FLT-3 Negative acute myeloblastic leukemia, with 20% blasts. The pregnancy ended without incident at 15 weeks, by means of a voluntary interruption of the pregnancy, after receiving information on the diagnosis, prognosis and risk of teratogenicity from the treatment. Currently, the patient is on the waiting list for histocompatibility bone marrow transplant.  CONCLUSIONS: The importance of analytical control during pregnancy can allow an early diagnosis, to establish an immediate treatment, key for the prognosis. All this, in addition to the multidisciplinary approach and advice, is essential to ensure maternal and fetal well-being.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Leucemia mieloide aguda]]></kwd>
<kwd lng="es"><![CDATA[embarazo]]></kwd>
<kwd lng="es"><![CDATA[primer trimestre del embarazo]]></kwd>
<kwd lng="es"><![CDATA[seguimiento]]></kwd>
<kwd lng="es"><![CDATA[hematología]]></kwd>
<kwd lng="es"><![CDATA[pancitopenia]]></kwd>
<kwd lng="es"><![CDATA[laboratorio]]></kwd>
<kwd lng="es"><![CDATA[trasplante de médula ósea]]></kwd>
<kwd lng="es"><![CDATA[biopsia]]></kwd>
<kwd lng="es"><![CDATA[histocompatibilidad]]></kwd>
<kwd lng="en"><![CDATA[Acute myeloid leukemia]]></kwd>
<kwd lng="en"><![CDATA[Pregnancy]]></kwd>
<kwd lng="en"><![CDATA[First Pregnancy Trimester]]></kwd>
<kwd lng="en"><![CDATA[Follow up]]></kwd>
<kwd lng="en"><![CDATA[Hematology]]></kwd>
<kwd lng="en"><![CDATA[Pancytopenia]]></kwd>
<kwd lng="en"><![CDATA[Laboratory]]></kwd>
<kwd lng="en"><![CDATA[Bone marrow transplantation]]></kwd>
<kwd lng="en"><![CDATA[Biopsy]]></kwd>
<kwd lng="en"><![CDATA[Histocompatibility]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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