<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412021000600431</article-id>
<article-id pub-id-type="doi">10.24245/gom.v89i6.5264</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Asociación entre el volumen plaquetario medio y las concentraciones de ácido úrico como biomarcadores predictivos de preeclampsia]]></article-title>
<article-title xml:lang="en"><![CDATA[Association of levels of mean platelet volume and uric acid as predictive biomarkers of preeclampsia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hidalgo-Carrera]]></surname>
<given-names><![CDATA[Jaime Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chaya-Hajj]]></surname>
<given-names><![CDATA[Miguel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Linder-Efter]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Meden-Alarcon]]></surname>
<given-names><![CDATA[Jahn Werner Von der]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Borboa-Olivares]]></surname>
<given-names><![CDATA[Hector Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ayala-Yáñez]]></surname>
<given-names><![CDATA[Rodrigo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez-Valencia]]></surname>
<given-names><![CDATA[María Fernanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Médico ABC Departamento de Ginecología y Obstetricia ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>89</volume>
<numero>6</numero>
<fpage>431</fpage>
<lpage>437</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412021000600431&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412021000600431&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412021000600431&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  OBJETIVO: Determinar si la asociación entre la combinación de las concentraciones séricas del volumen plaquetario medio y las del ácido úrico determinadas en las semanas 20 a 24 del embarazo son predictoras de preeclampsia.  MATERIALES Y MÉTODOS: Estudio de casos y controles, retrospectivo y observacional consistente en el análisis del volumen plaquetario medio y de ácido úrico practicado entre las 20 a 24 semanas de embarazo. Variables de estudio: edad, índice de masa corporal mayor de 25 kg/m2 (sobrepeso y obesidad), paridad, antecedentes familiares de hipertensión arterial, realizar ejercicio (más de 150 minutos a la semana), valor plaquetario medio y concentraciones de ácido úrico tomados en las 20 a 24 semanas de embarazo, albúmina sérica y embarazo espontáneo o por técnicas de reproducción asistida. Los datos se analizaron en el paquete estadístico SPSS versión 25.  RESULTADOS: Se estudiaron 122 casos y 199 controles. Conforme al modelo de regresión logística ajustado se obtuvo una razón de momios (RM) para predecir preeclampsia de 4.383, con IC95%: 1.980-9.705 para la elevación del volumen plaquetario medio y una RM de 7.665 con IC95%: 3.415-17.204 para la elevación del ácido úrico (p &lt; 0.001). Las otras variables con relevancia estadística para riesgo de preeclampsia fueron: edad, antecedentes familiares de hipertensión arterial, concepción mediante técnicas de reproducción asistida, embarazo múltiple, ser primíparas y el sedentarismo como estilo de vida.  CONCLUSIÓN: Conforme a los resultados de este estudio el aumento del volumen plaquetario medio (más de 9.7 fL) y del ácido úrico (más de 4.9 mg/dL) entre las semanas 20 a 24 es un biomarcador predictivo de preeclampsia. Hacen falta más estudios al respecto para confirmar la validez y utilidad de estos hallazgos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  OBJECTIVE: To determine whether the association of the combination of serum concentrations of mean platelet volume and uric acid determined at 20 to 24 weeks of pregnancy are predictors of preeclampsia.  MATERIALS AND METHODS: Case-control, retrospective, observational study consisting of the analysis of mean platelet volume and uric acid between 20 and 24 weeks of pregnancy. Study variables: age, body mass index greater than 25 kg/m2 (overweight and obesity), parity, family history of hypertension, exercise (more than 150 minutes per week), mean platelet and uric acid concentrations taken at 20 to 24 weeks of pregnancy, serum albumin, and spontaneous or assisted reproductive techniques pregnancy. The data were analyzed in the SPSS version 25 statistical package.  RESULTS: A total of 122 cases and 199 controls were studied. According to the adjusted logistic regression model, we obtained an odds ratio (OR) for predicting preeclampsia of 4.383, with 95%CI: 1.980-9.705 for the elevation of mean platelet volume and an OR of 7.665 with 95%CI: 3.415-17.204 for the elevation of uric acid (p &lt; 0.001). The other variables with statistical significance for risk of preeclampsia were: age, family history of arterial hypertension, conception by assisted reproduction techniques, multiple pregnancy, being primiparous and sedentary lifestyle.  CONCLUSION: According to the results of this study, the increase in mean platelet volume (more than 9.7 fL) and uric acid (more than 4.9 mg/dL) between weeks 20 and 24 is a predictive biomarker of preeclampsia. Further studies are needed to confirm the validity and usefulness of these findings.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Volumen plaquetario medio]]></kwd>
<kwd lng="es"><![CDATA[ácido úrico]]></kwd>
<kwd lng="es"><![CDATA[preeclampsia, biomarcadores]]></kwd>
<kwd lng="en"><![CDATA[Mean platelet volume]]></kwd>
<kwd lng="en"><![CDATA[Uric Acid]]></kwd>
<kwd lng="en"><![CDATA[Pre-Eclampsia]]></kwd>
<kwd lng="en"><![CDATA[Biomarkers]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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