<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412021000300011</article-id>
<article-id pub-id-type="doi">10.24245/gom.v89i3.4716</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Tuberculosis congénita. Reporte de un caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Congenital tuberculosis. A case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Farías-Vela]]></surname>
<given-names><![CDATA[Adriana Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Daza-Leguizamón]]></surname>
<given-names><![CDATA[Deisy Yurany]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aragón-Mendoza]]></surname>
<given-names><![CDATA[Rafael Leonardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pulido-Rodríguez]]></surname>
<given-names><![CDATA[Melisa Fernanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario de la Samaritana  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Universitario de la Samaritana  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Universitario de la Samaritana  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>89</volume>
<numero>3</numero>
<fpage>267</fpage>
<lpage>273</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412021000300011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412021000300011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412021000300011&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  ANTECEDENTES:  La tuberculosis congénita es una infección bacteriana excepcional causada por el Mycobacterium tuberculosis. Su trasmisión es vertical madre-feto en el 16% de los casos. Puede ser por dos vías: trasplacentaria a través de la vena umbilical o por contaminación del líquido amniótico que puede aspirar o ingerir el feto. Su diagnóstico es desafiante, con síntomas inespecíficos. Se sospecha en los neonatos hijos de madres con tuberculosis; la mortalidad es alta.  CASO CLÍNICO:  Paciente de 30 años, con antecedente de asma leve intermitente en tratamiento con salbutamol, dos embarazos, un parto y un aborto y una gestación en curso de 35 semanas atendida en el Hospital Universitario de la Samaritana. Consultó debido a tener fiebre asociada con síntomas respiratorios, con baciloscopia positiva. Se diagnosticó tuberculosis pulmonar. Durante la hospitalización tuvo trabajo de parto pretérmino, con recién nacido vivo, que se aisló por el diagnóstico materno. Se le indicó tratamiento profiláctico con isoniazida; se diagnosticó tuberculosis congénita por PCR positiva para Mycobacterium tuberculosis en el jugo gástrico. El tratamiento se complementó con rifampicina, pirazinamida y etambutol, con los que la respuesta clínica fue favorable.  CONCLUSIÓN:  La tuberculosis congénita es una enfermedad infrecuente, con síntomas inespecíficos. Puede sospecharse en el recién nacido hijo de madre con ese diagnóstico o sin respuesta al tratamiento antibiótico tradicional o a la terapia de soporte en unidades de cuidado intensivo neonatal. El diagnóstico se basa en la detección microbiológica del bacilo. El tratamiento temprano se asocia con mejores desenlaces perinatales y disminución de la mortalidad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKGROUND:  Congenital tuberculosis is an exceptional bacterial infection caused by Mycobacterium tuberculosis. It is transmitted vertically from mother to fetus in 16% of cases. It can be by two routes: transplacental through the umbilical vein or by contamination of the amniotic fluid that can be aspirated or ingested by the fetus. Its diagnosis is challenging, with nonspecific symptoms. It is suspected in neonates born to mothers with tuberculosis; mortality is high.  CLINICAL CASE:  A 30-year-old patient with a history of mild intermittent asthma treated with salbutamol, two pregnancies, one delivery and one miscarriage and an ongoing gestation of 35 weeks at the Hospital Universitario de la Samaritana. She consulted due to fever associated with respiratory symptoms, with positive bacilloscopy. Pulmonary tuberculosis was diagnosed. During hospitalization she had preterm labor, with live newborn, which was isolated due to maternal diagnosis. Prophylactic treatment with isoniazid was indicated; congenital tuberculosis was diagnosed by positive PCR for Mycobacterium tuberculosis in gastric juice. Treatment was complemented with rifampicin, pyrazinamide and ethambutol, with which the clinical response was favorable.  CONCLUSION:  Congenital tuberculosis is a rare disease, with nonspecific symptoms. It may be suspected in the newborn child of a mother with this diagnosis or without response to traditional antibiotic treatment or supportive therapy in neonatal intensive care units. Diagnosis is based on microbiological detection of the bacillus. Early treatment is associated with better perinatal outcomes and decreased mortality.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Tuberculosis congénita]]></kwd>
<kwd lng="es"><![CDATA[Mycobacterium tuberculosis]]></kwd>
<kwd lng="es"><![CDATA[vena umbilical]]></kwd>
<kwd lng="es"><![CDATA[líquido amniótico]]></kwd>
<kwd lng="en"><![CDATA[Congenital tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[Mycobacterium tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[Umbilical vein]]></kwd>
<kwd lng="en"><![CDATA[Amniotic fluid]]></kwd>
</kwd-group>
</article-meta>
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</ref-list>
</back>
</article>
