<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412021000100084</article-id>
<article-id pub-id-type="doi">10.24245/gom.v89i1.4363</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Small cell ovarian carcinoma of the hypercalcemic subtype: a case report]]></article-title>
<article-title xml:lang="es"><![CDATA[Tumor de células pequeñas del ovario del subtipo hipercalcémico: reporte de un caso]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes-Tobar]]></surname>
<given-names><![CDATA[Paulina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Altamirano-Assad]]></surname>
<given-names><![CDATA[Roberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Osses-Donoso]]></surname>
<given-names><![CDATA[Letsy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nazzal-Nazal]]></surname>
<given-names><![CDATA[Omar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Suárez-Pacheco]]></surname>
<given-names><![CDATA[Eugenio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Clínico San Borja Arriarán  ]]></institution>
<addr-line><![CDATA[Santiago ]]></addr-line>
<country>Chile</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Clínico San Borja Arriarán  ]]></institution>
<addr-line><![CDATA[Santiago ]]></addr-line>
<country>Chile</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>89</volume>
<numero>1</numero>
<fpage>84</fpage>
<lpage>89</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412021000100084&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412021000100084&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412021000100084&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  BACKGROUND: Small cell ovarian carcinoma of the hypercalcemic subtype (SCCOHT) is a rare and aggressive ovarian neoplasm that affects more frequently to young women, its landmark is the elevation of serum calcium and somatic mutations of the SMARC4 gen.  CLINICAL CASE: We present a case report of a 22 year old woman who attended to our emergency service due to a 48 hours long abdominal pain, at her arrival a transvaginal ultrasound was performed which showed a right adnexal, solid, 15 centimeters in size tumor, clinical examination was compatible with an acute abdomen. She underwent an emergency right salpingo oophorectomy because of the tumor was twisted, without other pathologic findings in the surgery. Serum markers where obtained, except for calcium, only lactate dehydrogenase was altered. The biopsy described a SCCOHT affecting the right ovary, because of these, a staging surgery (FIGO IIIC) follow by platinum-based chemotherapy and radiotherapy were performed, with good response from a clinical and imaging point of view. There are not been signs of recurrence up to her last appointment, in September 2019.  CONCLUSIONS:  Regarding the treatment, there are no guidelines, but combine treatment: unconservative surgery along with chemotherapy and radiation seems to improve the outcome, despite this, the overall survival is low. Genetics techniques could play a key role in diagnosis and treatment.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  ANTECEDENTES: El tumor de células pequeñas del ovario, del subtipo hipercalcémico (SCCOHT), es una neoplasia ovárica rara y agresiva, que afecta sobre todo a mujeres jóvenes. Destacan la elevación del calcio sérico y las mutaciones somáticas del gen SMARC4.  CASO CLÍNICO:  Paciente de 22 años que acudió a urgencias debido a un dolor abdominal de 48 horas de evolución. La ecografía transvaginal mostró un tumor sólido de 15 centímetros en el anexo derecho. El examen físico fue compatible con abdomen agudo. Se decidió la salpingooforectomía debido a que el tumor estaba torcido, sin otros hallazgos patológicos en la cirugía. Se obtuvieron marcadores séricos, excepto del calcio y solo la deshidrogenasa láctica se reportó alterada. La biopsia describió un SCCOHT que afectaba el ovario derecho; por esto se practicó una cirugía etapificadora (FIGO IIIC) seguida de quimioterapia con platino y radioterapia, con buena respuesta clínica e imagenológica. Hasta su último control médico en septiembre de 2019 se encontraba sin evidencia de recurrencia.  CONCLUSIONES: Si bien no existen guías de tratamiento, el combinado con cirugía no conservadora, quimio y radioterapia al parecer mejora el desenlace, aunque la supervivencia es baja. Las técnicas genéticas tienen una participación decisiva en el diagnóstico y tratamiento.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Small cell ovarian carcinoma]]></kwd>
<kwd lng="en"><![CDATA[Hypercalcemia]]></kwd>
<kwd lng="en"><![CDATA[SCCOHT]]></kwd>
<kwd lng="en"><![CDATA[Ovarian neoplasm]]></kwd>
<kwd lng="en"><![CDATA[Mutations]]></kwd>
<kwd lng="en"><![CDATA[Abdomen acute]]></kwd>
<kwd lng="en"><![CDATA[Biomarkers]]></kwd>
<kwd lng="es"><![CDATA[Carcinoma de ovario de células pequeñas]]></kwd>
<kwd lng="es"><![CDATA[hipercalcemia]]></kwd>
<kwd lng="es"><![CDATA[SCCOHT]]></kwd>
<kwd lng="es"><![CDATA[neoplasia de ovario]]></kwd>
<kwd lng="es"><![CDATA[mutaciones]]></kwd>
<kwd lng="es"><![CDATA[abdomen agudo]]></kwd>
<kwd lng="es"><![CDATA[biomarcadores]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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