<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412021000100077</article-id>
<article-id pub-id-type="doi">10.24245/gom.v89i1.4361</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Afectación mamaria bilateral como primera manifestación de leucemia-linfoma linfoide aguda de células T]]></article-title>
<article-title xml:lang="en"><![CDATA[Bilateral breast disease as the first manifestation of acute T-cell leukemia/lymphoma]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Laguna-Olmos]]></surname>
<given-names><![CDATA[Mariano]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz-Peña]]></surname>
<given-names><![CDATA[Ana Cristina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández-García]]></surname>
<given-names><![CDATA[Cristina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Esteban-Figuerola]]></surname>
<given-names><![CDATA[Ada]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Atienza-Roles]]></surname>
<given-names><![CDATA[Marta]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peralta-Benítez]]></surname>
<given-names><![CDATA[Raiza Soraya]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital San Pedro  ]]></institution>
<addr-line><![CDATA[Logroño La Rioja]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital San Pedro  ]]></institution>
<addr-line><![CDATA[Logroño La Rioja]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital San Pedro  ]]></institution>
<addr-line><![CDATA[Logroño La Rioja]]></addr-line>
<country>España</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital San Pedro  ]]></institution>
<addr-line><![CDATA[Logroño La Rioja]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>89</volume>
<numero>1</numero>
<fpage>77</fpage>
<lpage>83</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412021000100077&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412021000100077&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412021000100077&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  ANTECEDENTES: Las neoplasias hematológicas de la mama son un cuadro poco frecuente, sobre todo como primera manifestación de la enfermedad y de células T.  OBJETIVO: Comunicar un caso clínico de leucemia-linfoma linfoide aguda de células T que se inició en forma de nódulos palpables bilaterales en la mama, su epidemiología, características clínicas, diagnósticas y tratamiento.  CASO CLÍNICO:  Paciente de 34 años, remitida de la atención primaria a la Unidad de Mama del Hospital San Pedro después de palparse dos nódulos no dolorosos en la mama derecha y uno en la izquierda de un mes de evolución. El estudio ecográfico evidenció un nódulo redondeado, contorno circunscrito e isodenso de 12 mm en la mama izquierda. En la mama contralateral se objetivó otro nódulo de similares características junto con adenopatías bilaterales. Los estudios histológico, inmunofenotípico y de extensión permitieron establecer el diagnóstico de leucemia-linfoma linfoide aguda t-tímica cortical aguda (T-III según OMS 2016) de alto riesgo, con afectación sistémica. Se inició la quimioterapia de inducción conforme al protocolo PETHEMA LAL-AR/11. Desde el inicio del tratamiento la paciente experimentó una enfermedad mínima residual negativa, sin que fuera necesario el trasplante de progenitores hematopoyéticos, a pesar de su condición de alto riesgo.  CONCLUSIONES: La infiltración leucémica de la mama es excepcional, sobre todo cuando se trata de la primera manifestación de la enfermedad. En el diagnóstico diferencial de pacientes jóvenes, con lesiones múltiples y bilaterales en la mama sospechosas de malignidad, deben incluirse las neoplasias hematológicas malignas e iniciar el estudio necesario para descartarlas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  BACKGROUND: Breast hematologic malignancies are a rare condition, even more if they appear as the first manifestation of the disease and if they are T cells tumors.  OBJECTIVE:  The objective is to present a case report of an acute T-cell leukemia / lymphoma that started with breast bilateral palpable nodules, as well as to review its epidemiology, clinical characteristics, diagnosis and treatment.  CASE REPORT:  34-year-old woman, referred from primary care to the Breast Unit of our center after feeling two painless nodules in the right breast and one in the left breast for one month. The ultrasound study showed the presence in the left breast of a 12 mm rounded, isodense nodule with circumscribed outline. Another nodule with similar characteristics was observed in the contralateral breast along with bilateral lymphadenopathy. The histological, immunophenotypic and extension study diagnosed an Acute Cortical T-Thymic Leukemia / Lymphoid Lymphoma (T-III according to WHO 2016) with High Risk with systemic involvement of the disease and started chemotherapy induction treatment according to the PETHEMA LAL-AR/11 protocol. The patient presented a minimal negative residual disease from the start of the treatment without requiring an hematopoietic parents transplant despite being a high-risk case.  CONCLUSIONS: Breast leukemic infiltration is a rare entity, even more if it constitutes the first manifestation of the disease. The presence of multiple bilateral breast nodules suspected as malignant in young patients, should include hematological malignancies in the differential diagnosis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Neoplasias hematológicas de la mama]]></kwd>
<kwd lng="es"><![CDATA[células T]]></kwd>
<kwd lng="es"><![CDATA[leucemia-linfoma linfoide aguda de células T]]></kwd>
<kwd lng="es"><![CDATA[diagnóstico diferencial]]></kwd>
<kwd lng="es"><![CDATA[neoplasias de la mama]]></kwd>
<kwd lng="en"><![CDATA[Breast hematologic malignancies]]></kwd>
<kwd lng="en"><![CDATA[T cells]]></kwd>
<kwd lng="en"><![CDATA[Acute T cell Leukaemia Lymphoma]]></kwd>
<kwd lng="en"><![CDATA[Leukemic infiltration]]></kwd>
<kwd lng="en"><![CDATA[Precursor T-Cell lymphoblastic Leukemia-lymphoma]]></kwd>
<kwd lng="en"><![CDATA[Diagnosis differential]]></kwd>
<kwd lng="en"><![CDATA[Breast Neoplasms]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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