<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412020000600357</article-id>
<article-id pub-id-type="doi">10.24245/gom.v88i6.3752</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Combinación del ácido úrico y albúmina sérica como biomarcadores predictivos de preeclampsia severa]]></article-title>
<article-title xml:lang="en"><![CDATA[Combination of uric acid and serum albumin as predictive biomarkers of severe preeclampsia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hidalgo-Carrera]]></surname>
<given-names><![CDATA[Jaime Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Linder-Efter]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chaya-Hajj]]></surname>
<given-names><![CDATA[Miguel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Meden-Alarcón]]></surname>
<given-names><![CDATA[J. Werner Von der]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Lane]]></surname>
<given-names><![CDATA[Rebeca]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez-Valencia]]></surname>
<given-names><![CDATA[María Fernanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Médico ABC Departamento de Ginecología y Obstetricia ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<volume>88</volume>
<numero>6</numero>
<fpage>357</fpage>
<lpage>362</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412020000600357&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412020000600357&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412020000600357&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  OBJETIVO: Establecer si la la combinación de las concentraciones séricas de ácido úrico y albúmina en las semanas 20 a 24 del embarazo es predictora de preeclampsia severa.  MATERIALES Y MÉTODOS:  Estudio de casos y controles, retrospectivo y observacional, en el que se analizaron las concentraciones de ácido úrico y de albúmina coexistentes en las semanas 20 a 24; posteriormente se compararon las diferencias con pacientes con preeclampsia severa. Se recabaron los datos en Microsoft Excel para Mac versión 2019 y el análisis estadístico se realizó en SPSS para Mac versión 25.  RESULTADOS: Se obtuvieron 122 casos y 199 controles. La elevación de las concentraciones de ácido úrico (&#8805; 4.9 mg/dL) y la hipoalbuminemia (menos de 3.5 mg/dL) tuvieron significación estadística para preeclampsia severa versus el grupo control (p &lt; 0.001). El modelo de regresión logística obtuvo una razón de momios para predecir preeclampsia con datos de severidad de 6.736 (IC95%: 2.5-17.7) para la elevación del ácido úrico y razón de momios de 11.337 (IC95%: 4.5-28.3) para la hipoalbuminemia (p &lt; 0.001).  CONCLUSIÓN: El aumento en las concentraciones de ácido úrico (medidas entre las semanas 20 a 24 de embarazo) en combinación con la albúmina sérica tiene utilidad predictora de preeclampsia severa. Sin embargo, deben efectuarse más estudios clínicos para comprobar su eficacia y poder reducir la prevalencia de esta enfermedad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  OBJECTIVE: To determine if the combination of serum uric acid and albumin levels from weeks 20 to 24 of gestation are predictors of severe preeclampsia.  MATERIALS AND METHODS:  A retrospective and observational case-control study was carried out, in which the levels of uric acid and albumin taken during the 20th to 24th week were analyzed and compared with patients who developed severe preeclampsia. The data was collected in Microsoft Excel for Mac version 2019 and the statistical analysis was performed in SPSS for Mac version 25.  RESULTS: 122 cases and 199 controls were obtained. Elevation of uric acid levels (&#8805;4.9 mg/dL) and hypoalbuminemia (&lt;3.5 mg/dL) obtained statistical significance for severe preeclampsia compared to the control group (p &lt;0.001). The logistic regression model obtained an OR to predict severe preeclampsia of 6.736 (CI95% 2.5-17.7) for uric acid elevation and OR of 11.337 (CI95% 4.5-28.3) for hypoalbuminemia (p &lt;0.001).  CONCLUSION:  In this study the statistically significant relationship was observed between the increase in uric acid levels and serum hypoalbuminemia from weeks 20 to 24 as predictive biomarkers of severe preeclampsia. However, more studies should be carried out to verify its clinical utility.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Ácido úrico sérico]]></kwd>
<kwd lng="es"><![CDATA[preeclampsia severa]]></kwd>
<kwd lng="es"><![CDATA[ácido úrico]]></kwd>
<kwd lng="es"><![CDATA[albúmina]]></kwd>
<kwd lng="es"><![CDATA[hipoalbuminemia]]></kwd>
<kwd lng="es"><![CDATA[biomarcadores]]></kwd>
<kwd lng="en"><![CDATA[Serum uric acid]]></kwd>
<kwd lng="en"><![CDATA[Severe preeclampsia]]></kwd>
<kwd lng="en"><![CDATA[Uric acid]]></kwd>
<kwd lng="en"><![CDATA[Albumin]]></kwd>
<kwd lng="en"><![CDATA[Hypoalbuminemia]]></kwd>
<kwd lng="en"><![CDATA[Biomarkers]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rezk]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[First versus second trimester mean platelet volume and uric acid for prediction of preeclampsia in women at moderate and low risk]]></article-title>
<source><![CDATA[Hypertension in pregnancy]]></source>
<year>2018</year>
<volume>37</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Soeters]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hypoalbuminemia: Pathogenesis and Clinical Significance]]></article-title>
<source><![CDATA[JPEN J Parenter Enteral Nutr]]></source>
<year>2019</year>
<volume>43</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>181-93</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Association of hypoproteinemia in preeclampsia with maternal and perinatal outcomes: A retrospective analysis of high-risk women]]></article-title>
<source><![CDATA[J Res Med Sci]]></source>
<year>2016</year>
<volume>21</volume>
<page-range>98</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gojnic]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Plasma albumin level as an indicator of severity of preeclampsia]]></article-title>
<source><![CDATA[Clin Exp Obstet Gynecol]]></source>
<year>2004</year>
<volume>31</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>209-10</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pasyar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Investigating the diagnostic capacity of uric acid in the occurrence of preeclampsia]]></article-title>
<source><![CDATA[Pregnancy Hypertension]]></source>
<year>2020</year>
<volume>19</volume>
<page-range>106-11</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gómez]]></surname>
<given-names><![CDATA[LM.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Actualización en la fisiopatología de la preeclampsia]]></article-title>
<source><![CDATA[Rev Peru Ginecol Obstet]]></source>
<year>2014</year>
<volume>60</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>321-31</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Benoit]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Preeclampsia: should plasma albumin level be a criterion for severity?]]></article-title>
<source><![CDATA[J Obstet Gynaecol Can]]></source>
<year>2011</year>
<volume>33</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>922-6</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yescas-Osorio]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Correlación de la concentración sérica de ácido úrico en pacientes con preeclampsia severa en la unidad de cuidados intensivos]]></article-title>
<source><![CDATA[Ginecol Obstet Mex]]></source>
<year>2017</year>
<volume>85</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>347-54</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ghazali]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Study of the clinical significance of serum albumin level in preeclampsia and in the detection of its severity]]></article-title>
<source><![CDATA[American Journal of BioMedicine]]></source>
<year>2014</year>
<volume>2</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>899-902</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Seong]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical significance of serum albumin level in pregnancy-related hypertension]]></article-title>
<source><![CDATA[J Obstet Gynaecol Res]]></source>
<year>2010</year>
<volume>36</volume>
<numero>6</numero>
<issue>6</issue>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bainbridge]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Uric acid as a pathogenic factor in pre-eclampsia.]]></article-title>
<source><![CDATA[Placenta]]></source>
<year>2008</year>
<volume>29</volume>
<page-range>S67-72</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Álvarez]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[El ácido úrico como factor predictor de la preeclampsia]]></article-title>
<source><![CDATA[Revista Cubana de Obstetricia y Ginecología]]></source>
<year>2018</year>
<volume>44</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Devgun]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Importance of diurnal variations on clinical value and interpretation of serum urate measurements]]></article-title>
<source><![CDATA[J Clin Pathol]]></source>
<year>1992</year>
<volume>45</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>110-3</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Uric acid levels in gestational hypertensive women predict preeclampsia and outcome of small-for-gestational-age infants]]></article-title>
<source><![CDATA[J Matern Fetal Neonatal Med]]></source>
<year>2019</year>
<page-range>1-7</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chescheir]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serum uric acid measurement in women with hypertensive disorders of pregnancy]]></article-title>
<source><![CDATA[Obstetrics &amp; Gynecology]]></source>
<year>2019</year>
<volume>134</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>636-8</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ryu]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Predictive value of serum uric acid levels for adverse perinatal outcomes in preeclampsia]]></article-title>
<source><![CDATA[Medicine]]></source>
<year>2019</year>
<volume>98</volume>
<numero>18</numero>
<issue>18</issue>
</nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cohen]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of fetal number on maternal serum uric acid concentration]]></article-title>
<source><![CDATA[Am J Perinatol]]></source>
<year>2002</year>
<volume>19</volume>
<page-range>291-6</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Le]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Maternal serum uric acid concentration and pregnancy outcomes in women with pre-eclampsia/eclampsia]]></article-title>
<source><![CDATA[Int J Gynaecol Obstet]]></source>
<year>2018</year>
<volume>144</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>21-6</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Duan]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Alterations of several serum parameters are associated with preeclampsia and may be potential markers for the assessment of PE severity]]></article-title>
<source><![CDATA[Disease Markers]]></source>
<year>2020</year>
<volume>2020</volume>
<page-range>1-7</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
