<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0188-6266</journal-id>
<journal-title><![CDATA[Acta universitaria]]></journal-title>
<abbrev-journal-title><![CDATA[Acta univ]]></abbrev-journal-title>
<issn>0188-6266</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Guanajuato, Dirección de Investigación y Posgrado]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0188-62662021000100130</article-id>
<article-id pub-id-type="doi">10.15174/au.2021.3181</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[BK-Channels: Simulador de corriente macroscópica (IBK) para la investigación y la enseñanza-aprendizaje]]></article-title>
<article-title xml:lang="en"><![CDATA[BK-Channels: Macroscopic current simulator (IBK) for research and teaching-learning]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes Monreal]]></surname>
<given-names><![CDATA[Marleni]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Bonilla]]></surname>
<given-names><![CDATA[María Eugenia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quintero Pérez]]></surname>
<given-names><![CDATA[Jessica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Escalera]]></surname>
<given-names><![CDATA[Miguel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes Lazalde]]></surname>
<given-names><![CDATA[Arturo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Benemérita Universidad Autónoma de Puebla  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Benemérita Universidad Autónoma de Puebla Facultad de Ciencias Biológicas Laboratorio de Biología Interactiva]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Benemérita Universidad Autónoma de Puebla Facultad de Medicina Escuela de Fisioterapia]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>31</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0188-62662021000100130&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0188-62662021000100130&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0188-62662021000100130&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Las prácticas de laboratorio virtuales adquieren relevancia en tiempos de pandemia. En este estudio se presenta un simulador de los canales de K+ de alta conductancia (BK) con fines de investigación y de enseñanza-aprendizaje. Estos canales están relacionados con epilepsia e hipertensión arterial. El simulador está basado en el modelo matemático de Gupta y Manchanda, y se implementó en Visual Basic 6.0 para ambiente Windows®. El simulador reproduce los datos experimentales publicados de la cinética de la corriente macroscópica BK de canales transfectados en diferentes células. Los datos simulados y los experimentales no presentaron diferencias (p &gt; 0.05). Con el simulador se pueden realizar experimentos virtuales; determinar parámetros como la sensibilidad al Ca2+ (&#916;V1/2), la dependencia de Ca2+ interno y de voltaje; y reproducir la relación conductancia-voltaje (G-V). El simulador es ejecutable en cualquier computadora con recursos mínimos y puede ser utilizado como herramienta didáctica en cursos presenciales y a distancia.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Virtual laboratory practices become relevant in times of pandemic. In this study, a simulator of high-conductance K+ channels (BK) is presented for research and teaching-learning purposes. These channels are related to diseases such as epilepsy and high blood pressure. The simulator is based on the mathematical model of Gupta and Manchanda, and it was implemented in Visual Basic 6.0 for Windows®. The simulator reproduces the published experimental data of the macroscopic BK current kinetics of transfected channels in different cells. The simulated and experimental data did not show differences (p &gt; 0.05). Through the simulator, virtual experiments can be performed; parameters such as Ca2+ sensitivity (&#916;V1/2), internal Ca2+, and voltage dependence can be determined; and the conductance-voltage relationship (G-V) can be reproduced. The simulator is executable on any PC with minimal resources, and it can be used as a teaching tool in classroom and distance learning courses.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Simuladores electrofisiológicos]]></kwd>
<kwd lng="es"><![CDATA[canales BK]]></kwd>
<kwd lng="es"><![CDATA[curvas G-V]]></kwd>
<kwd lng="es"><![CDATA[corriente BK]]></kwd>
<kwd lng="es"><![CDATA[herramientas didácticas]]></kwd>
<kwd lng="en"><![CDATA[Electrophysiological simulators]]></kwd>
<kwd lng="en"><![CDATA[BK channels]]></kwd>
<kwd lng="en"><![CDATA[G-V curves]]></kwd>
<kwd lng="en"><![CDATA[BK stream]]></kwd>
<kwd lng="en"><![CDATA[teaching tools]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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