<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-4866</journal-id>
<journal-title><![CDATA[Medicina interna de México]]></journal-title>
<abbrev-journal-title><![CDATA[Med. interna Méx.]]></abbrev-journal-title>
<issn>0186-4866</issn>
<publisher>
<publisher-name><![CDATA[Edición y Farmacia S.A. de C.V.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-48662019000400501</article-id>
<article-id pub-id-type="doi">10.24245/mim.v35i4.2434</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Asociación de disfunción tiroidea subclínica con el síndrome de fragilidad en pacientes adultos mayores]]></article-title>
<article-title xml:lang="en"><![CDATA[Relation of subclinical thyroid dysfunction to frailty syndrome in older patients]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Prado-Hernández]]></surname>
<given-names><![CDATA[Oscar Anastacio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vega-Quintana]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moreno-Cervantes]]></surname>
<given-names><![CDATA[César Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Luna-Torres]]></surname>
<given-names><![CDATA[Sara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres-Gutiérrez]]></surname>
<given-names><![CDATA[Jorge Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Hospital Regional del Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado ]]></institution>
<addr-line><![CDATA[León Guanajuato]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>35</volume>
<numero>4</numero>
<fpage>501</fpage>
<lpage>506</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-48662019000400501&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-48662019000400501&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-48662019000400501&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  OBJETIVO: Evaluar la asociación entre disfunción tiroidea subclínica y síndrome de fragilidad en pacientes adultos mayores.  MATERIAL Y MÉTODO: Estudio de casos y controles efectuado de enero de 2016 a junio de 2017 en adultos mayores con síndrome de fragilidad (casos) y sin síndrome de fragilidad (controles). El diagnóstico de síndrome de fragilidad se estableció con los criterios de Fried. Se compararon las concentraciones séricas de TSH y T4 libre en pacientes robustos, prefrágiles y frágiles. También se determinó la razón de momios (OR) para fragilidad en pacientes con hipotiroidismo subclínico e hipertiroidismo subclínico.  RESULTADOS: La edad promedio de los casos (n = 100) y controles (n = 104) fue de 83.2 y 78.1 años, respectivamente (p &#8804; 0.01). Las concentraciones de TSH en sujetos frágiles en comparación con pacientes robustos fueron 3.1 vs 2.7 ng/mL (p = 0.5) y las concentraciones séricas de T4 libre fueron 1.26 y 1.32 ng/dL, respectivamente (p = 0.315). El OR para fragilidad en pacientes con hipotiroidismo subclínico fue de 1.21 (IC95% 0.39-3.80, p = 0.740) y en pacientes con hipertiroidismo subclínico fue OR = 0.74 (IC95% 0.14-3.75, p = 0.714).  CONCLUSIONES: No existen diferencias significativas en las concentraciones séricas de TSH ni T4 libre entre pacientes frágiles y robustos. El hipotiroidismo y el hipertiroidismo subclínico no se asociaron con mayor riesgo de síndrome de fragilidad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  OBJECTIVE: To evaluate the association between subclinical thyroid dysfunction and frailty syndrome in elderly patients.  MATERIAL AND METHOD: A case-control study was carried out from January 2016 to June 2017 in older adults with frailty syndrome (cases) and without frailty syndrome (controls). The diagnosis of frailty syndrome was made according to the Fried criteria. The serum levels of TSH and free-T4 were compared in robust, pre-frailty and frailty patients. Also, the odds ratio (OR) for frailty was determined in patients with subclinical hypothyroidism and subclinical hyperthyroidism.  RESULTS: The mean age of the cases (n = 100) and controls (n = 104) was 83.2 and 78.1 years, respectively (p &#8804; 0.01). The TSH levels in fragile and robust were 3.1 and 2.7 ng/ mL (p = 0.594) and the serum levels of free T4 were 1.26 and 1.32 ng/dL, respectively (p = 0.315). The OR for fragility in patients with subclinical hypothyroidism was 1.21 (CI95% 0.39-3.80, p = 0.740) and in patients with subclinical hyperthyroidism it was of 0.74 (CI95% 0.14-3.75, p = 0.714).  CONCLUSIONS: There are no significant differences in serum levels of TSH or free T4 between fragile and robust patients. Subclinical hyperthyroidism and hypothyroidism were not associated with an increased risk of frailty syndrome.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Disfunción tiroidea]]></kwd>
<kwd lng="es"><![CDATA[síndrome de fragilidad]]></kwd>
<kwd lng="es"><![CDATA[vejez]]></kwd>
<kwd lng="en"><![CDATA[Thyroid dysfunction]]></kwd>
<kwd lng="en"><![CDATA[Frailty syndrome]]></kwd>
<kwd lng="en"><![CDATA[Elderly]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<collab>Organización de las Naciones Unidas</collab>
<source><![CDATA[La situación demográfica en el mundo, 2014: informe conciso]]></source>
<year>2014</year>
<publisher-loc><![CDATA[New York ]]></publisher-loc>
<publisher-name><![CDATA[Departamento de Asuntos Económicos y Sociales]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="book">
<collab>Instituto Nacional de Estadística y Geografía</collab>
<source><![CDATA[Estadísticas a propósito del día internacional de las personas de edad 2013]]></source>
<year>2013</year>
<publisher-loc><![CDATA[Aguascalientes ]]></publisher-loc>
<publisher-name><![CDATA[INEGI]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="">
<collab>Consejo Nacional de Población</collab>
<source><![CDATA[Datos de Proyecciones del Consejo Nacional de Población CONAPO]]></source>
<year>2017</year>
<publisher-loc><![CDATA[México ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Xue]]></surname>
<given-names><![CDATA[QL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The frailty syndrome definition and natural history]]></article-title>
<source><![CDATA[Clin Geriatr Med]]></source>
<year>2011</year>
<volume>27</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-15</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Clegg]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Young]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The frailty syndrome]]></article-title>
<source><![CDATA[Clin Med (Lond)]]></source>
<year>2011</year>
<volume>11</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>72-5</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shamliyan]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Talley]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
<name>
<surname><![CDATA[Ramakrishnan]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Kane]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Association of frailty with survival a systematic literature review]]></article-title>
<source><![CDATA[Ageing Res Rev]]></source>
<year>2013</year>
<volume>12</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>719-36</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Garcia-Garcia]]></surname>
<given-names><![CDATA[FJ]]></given-names>
</name>
<name>
<surname><![CDATA[Gutierrez Avila]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Alfaro-Acha]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Amor Andres]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[De Los Angeles]]></surname>
</name>
<name>
<surname><![CDATA[De La Torre Lanza]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Escribano Aparicio]]></surname>
<given-names><![CDATA[MV.]]></given-names>
</name>
<name>
<surname><![CDATA[Humanes Aparicio]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Larrion Zugasti]]></surname>
<given-names><![CDATA[JL.]]></given-names>
</name>
<name>
<surname><![CDATA[Gomez-Serranillo Reus]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Rodriguez-Artalejo]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Rodriguez-Manas]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<collab>Toledo Study Group</collab>
<article-title xml:lang=""><![CDATA[The prevalence of frailty syndrome in an older population from Spain The Toledo Study for Healthy Aging]]></article-title>
<source><![CDATA[J Nutr Health Aging]]></source>
<year>2011</year>
<volume>15</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>852-6</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Buckinx]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Rolland]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Reginster]]></surname>
<given-names><![CDATA[JY]]></given-names>
</name>
<name>
<surname><![CDATA[Ricour]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Petermans]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bruyère]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Burden of frailty in the elderly population perspectives for a public health challenge]]></article-title>
<source><![CDATA[Arch Public Health]]></source>
<year>2015</year>
<volume>73</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>19</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fried]]></surname>
<given-names><![CDATA[LP]]></given-names>
</name>
<name>
<surname><![CDATA[Tangen]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[Walston]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Frailty in older adults Evidence for phenotype]]></article-title>
<source><![CDATA[J Gerontol]]></source>
<year>2001</year>
<volume>56</volume>
<page-range>146-56</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fried]]></surname>
<given-names><![CDATA[LP]]></given-names>
</name>
<name>
<surname><![CDATA[Ferrucci]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Darer]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Williamson]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
<name>
<surname><![CDATA[Anderson]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Untangling the concepts of disability, frailty, and comorbidity implications for improved targeting and care]]></article-title>
<source><![CDATA[J Gerontol A Biol Sci Med Sci]]></source>
<year>2004</year>
<volume>59</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>255-63</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bellumkonda]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Tyrrell]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Hummel]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
<name>
<surname><![CDATA[Goldstein]]></surname>
<given-names><![CDATA[DR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pathophysiology of heart failure and frailty a common inflammatory origin?]]></article-title>
<source><![CDATA[Aging Cell]]></source>
<year>2017</year>
<volume>16</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>444-50</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Uchmanowicz]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Wleklik]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gobbens]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Frailty syndrome and self-care ability in elderly patients with heart failure]]></article-title>
<source><![CDATA[Clin Interv Aging]]></source>
<year>2015</year>
<volume>10</volume>
<page-range>871-7</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Mao]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Leng]]></surname>
<given-names><![CDATA[SX]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Frailty syndrome an overview]]></article-title>
<source><![CDATA[Clin Interv Aging]]></source>
<year>2014</year>
<volume>9</volume>
<page-range>433-41</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gielen]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Verschueren]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[O´Neill]]></surname>
<given-names><![CDATA[TW]]></given-names>
</name>
<name>
<surname><![CDATA[Pye]]></surname>
<given-names><![CDATA[SR]]></given-names>
</name>
<name>
<surname><![CDATA[O'Connell]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[DM.]]></given-names>
</name>
<name>
<surname><![CDATA[Ravindrarajah]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Claessens]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Laurent]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Milisen]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Tournoy]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Dejaeger]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[FC.]]></given-names>
</name>
<name>
<surname><![CDATA[Vanderschueren]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Boonen]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Musculoskeletal frailty a geriatric syndrome at the core of fracture occurrence in older age]]></article-title>
<source><![CDATA[Calcif Tissue Int]]></source>
<year>2012</year>
<volume>91</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>161-77</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Virgini]]></surname>
<given-names><![CDATA[VS]]></given-names>
</name>
<name>
<surname><![CDATA[Rodondi]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Cawthon]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
<name>
<surname><![CDATA[Harrison]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
<name>
<surname><![CDATA[Hoffman]]></surname>
<given-names><![CDATA[AR]]></given-names>
</name>
<name>
<surname><![CDATA[Orwoll]]></surname>
<given-names><![CDATA[ES]]></given-names>
</name>
<name>
<surname><![CDATA[Ensrud]]></surname>
<given-names><![CDATA[KE]]></given-names>
</name>
<name>
<surname><![CDATA[Bauer]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Subclinical Thyroid Dysfunction and Frailty Among Older Men]]></article-title>
<collab>Osteoporotic Fractures in Men MrOS Research Group</collab>
<source><![CDATA[J Clin Endocrinol Metab]]></source>
<year>2015</year>
<volume>100</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>4524-32</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yeap]]></surname>
<given-names><![CDATA[BB]]></given-names>
</name>
<name>
<surname><![CDATA[Alfonso]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Chubb]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
<name>
<surname><![CDATA[Walsh]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<name>
<surname><![CDATA[Hankey]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
<name>
<surname><![CDATA[Almeida]]></surname>
<given-names><![CDATA[OP]]></given-names>
</name>
<name>
<surname><![CDATA[Flicker]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Higher free thyroxine levels are associated with frailty in older men the Health In Men Study]]></article-title>
<source><![CDATA[Clin Endocrinol (Oxf)]]></source>
<year>2012</year>
<volume>76</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>741-8</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Michel]]></surname>
<given-names><![CDATA[JO]]></given-names>
</name>
<name>
<surname><![CDATA[Lang]]></surname>
<given-names><![CDATA[PO]]></given-names>
</name>
<name>
<surname><![CDATA[Zekry]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The frailty process update of the phenotype and preventive strategies]]></article-title>
<source><![CDATA[Ann Gerontol]]></source>
<year>2008</year>
<volume>1</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-7</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Paganelli]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Di Iorio]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cherubini]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Lauretani]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Mussi]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Volpato]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Frailty of older age The role of the endocrine-immune interaction]]></article-title>
<source><![CDATA[Current Pharmaceutical Design]]></source>
<year>2006</year>
<volume>12</volume>
<page-range>3147-59</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hershman]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Pekary]]></surname>
<given-names><![CDATA[AE]]></given-names>
</name>
<name>
<surname><![CDATA[Berg]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Solomon]]></surname>
<given-names><![CDATA[DH]]></given-names>
</name>
<name>
<surname><![CDATA[Sawin]]></surname>
<given-names><![CDATA[CT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serum thyrotropin and thyroid hormone levels in elderly and middle-aged euthyroid persons]]></article-title>
<source><![CDATA[J Am Geriatr Soc]]></source>
<year>1993</year>
<volume>41</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>823-8</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Checar]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Clin Endocrinol Metab]]></source>
<year>2012</year>
<volume>97</volume>
<page-range>3944-50</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bauer]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
<name>
<surname><![CDATA[Ettinger]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Nevitt]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Stone]]></surname>
<given-names><![CDATA[KL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Risk for fracture in women with low serum levels of thyroid-stimulating hormone]]></article-title>
<source><![CDATA[Ann Intern Med]]></source>
<year>2001</year>
<volume>134</volume>
<page-range>561-8</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
<name>
<surname><![CDATA[Buzková]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Fink]]></surname>
<given-names><![CDATA[HA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Subclinical thyroid dysfunction and incident hip fracture in older adults]]></article-title>
<source><![CDATA[Arch Intern Med]]></source>
<year>2010</year>
<volume>170</volume>
<page-range>1876-83</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vadiveloo]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Donnan]]></surname>
<given-names><![CDATA[PT]]></given-names>
</name>
<name>
<surname><![CDATA[Cochrane]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Leese]]></surname>
<given-names><![CDATA[GP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Thyroid Epidemiology, Audit, and Research Study (TEARS): the natural history of endogenous subclinical hyperthyroidism]]></article-title>
<source><![CDATA[J Clin Endocrinol Metab]]></source>
<year>2011</year>
<volume>96</volume>
<page-range>E1-8</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ceresini]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Lauretani]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Maggio]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Thyroid function abnormalities and cognitive impairment in elderly people results of the Invecchiare in Chianti study]]></article-title>
<source><![CDATA[J Am Geriatr Soc]]></source>
<year>2009</year>
<volume>57</volume>
<page-range>89-93</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[van den Beld]]></surname>
<given-names><![CDATA[AW]]></given-names>
</name>
<name>
<surname><![CDATA[Visser]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
<name>
<surname><![CDATA[Feelders]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Grobbee]]></surname>
<given-names><![CDATA[DE]]></given-names>
</name>
<name>
<surname><![CDATA[Lamberts]]></surname>
<given-names><![CDATA[SW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Thyroid hormone concentrations, disease, physical function, and mortality in elderly men]]></article-title>
<source><![CDATA[J Clin Endocrinol Metab]]></source>
<year>2005</year>
<volume>90</volume>
<page-range>6403-9</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Trivalle]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Doucet]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Chassagne]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Differences in the signs and symptoms of hyperthyroidism in older and younger patients]]></article-title>
<source><![CDATA[J Am Geriatr Soc]]></source>
<year>1996</year>
<volume>44</volume>
<page-range>50-3</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
