<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0035-0052</journal-id>
<journal-title><![CDATA[Revista mexicana de pediatría]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. pediatr.]]></abbrev-journal-title>
<issn>0035-0052</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Pediatría A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0035-00522023000400153</article-id>
<article-id pub-id-type="doi">10.35366/114765</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Tripsina inmunorreactiva para la detección de pacientes con fibrosis quística]]></article-title>
<article-title xml:lang="en"><![CDATA[Immunoreactive trypsin for the detection of cystic fibrosis patients]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Desvaux-García]]></surname>
<given-names><![CDATA[Miriam]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martín-de Vicente]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Romero]]></surname>
<given-names><![CDATA[Ruth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario Infantil Miguel Servet  ]]></institution>
<addr-line><![CDATA[Zaragoza ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Universitario Infantil Miguel Servet Unidad de Neumología y Fibrosis Quística Pediátrica ]]></institution>
<addr-line><![CDATA[Zaragoza ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Universitario Infantil Miguel Servet Unidad de Gastroenterología y Nutrición Infantil ]]></institution>
<addr-line><![CDATA[Zaragoza ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<volume>90</volume>
<numero>4</numero>
<fpage>153</fpage>
<lpage>155</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0035-00522023000400153&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0035-00522023000400153&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0035-00522023000400153&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  la fibrosis quística (FQ) es una enfermedad de herencia autosómica recesiva.  Objetivo:  describir el beneficio de la determinación de tripsina inmunorreactiva (TIR) para la detección de FQ, como parte del cribado neonatal.  Presentación del caso:  lactante de ocho meses con dos episodios de deshidratación hiponatrémica. Con estos antecedentes se sospechó FQ, ya que además presentaba niveles séricos elevados de TIR (130 ng/L). Se realizó el estudio genético para confirmar este diagnóstico, identificando una variante probablemente patogénica en el gen CFTR.  Conclusiones:  desde la etapa neonatal los niveles elevados de TIR pueden ayudar a la identificación de casos de FQ.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  cystic fibrosis (CF) is an autosomal recessive inherited disease.  Objective:  to describe the benefit of determination of immunoreactive trypsin (IRT) for the detection of CF, as part of neonatal screening.  Case presentation:  eight-month-old infant with two episodes of hyponatremic dehydration. With this history, CF was suspected since he had also high serum levels of IRT (130 ng/L). A genetic study confirmed CF, identifying a probably pathogenic variant in the CFTR gene.  Conclusions:  elevated TIR levels can help identify CF cases, from the neonatal period.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[fibrosis quística]]></kwd>
<kwd lng="es"><![CDATA[tripsina inmunorreactiva]]></kwd>
<kwd lng="es"><![CDATA[alcalosis metabólica]]></kwd>
<kwd lng="es"><![CDATA[cribado neonatal]]></kwd>
<kwd lng="en"><![CDATA[cystic fibrosis]]></kwd>
<kwd lng="en"><![CDATA[immunoreactive trypsin]]></kwd>
<kwd lng="en"><![CDATA[metabolic alkalosis]]></kwd>
<kwd lng="en"><![CDATA[neonatal screening]]></kwd>
</kwd-group>
</article-meta>
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