<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0035-001X</journal-id>
<journal-title><![CDATA[Revista mexicana de física]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. fis.]]></abbrev-journal-title>
<issn>0035-001X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Física]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0035-001X2016000300213</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Cervical cancer detection based on serum sample surface enhanced Raman spectroscopy]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez-Rojo]]></surname>
<given-names><![CDATA[S.A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Zerega]]></surname>
<given-names><![CDATA[B.E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Velázquez-Pedroza]]></surname>
<given-names><![CDATA[E.F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Espinosa]]></surname>
<given-names><![CDATA[J.C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres-González]]></surname>
<given-names><![CDATA[L.A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguilar-Lemarroy]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jave-Suárez]]></surname>
<given-names><![CDATA[L.F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Palomares-Anda]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Solís]]></surname>
<given-names><![CDATA[J.L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Guadalajara Centro Universitario de los Lagos ]]></institution>
<addr-line><![CDATA[Lagos de Moreno Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Politécnico Nacional  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Iberoamericana León  ]]></institution>
<addr-line><![CDATA[León Guanajuato]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Mexicano del Seguro Social  ]]></institution>
<addr-line><![CDATA[Guadalajara Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Instituto Mexicano del Seguro Social  ]]></institution>
<addr-line><![CDATA[León Gto]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2016</year>
</pub-date>
<volume>62</volume>
<numero>3</numero>
<fpage>213</fpage>
<lpage>218</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0035-001X2016000300213&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0035-001X2016000300213&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0035-001X2016000300213&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract In the presence of nanoparticles, the Raman signal is enhanced to the levels sufficient to detect a single molecule, therefore spectroscopy Surface-Enhanced Raman Scattering (SERS) is currently recognized as a detection technique extremely sensitive with high levels of molecular specificity. This is the first report in the cervical cancer detection based on serum SERS. The serum samples were obtained from 14 patients who were clinically diagnosed with cancer and 14 healthy volunteer controls. The serum samples were mixed with colloidal silver nanoparticles of 40 nm in the same proportion, using sonication. About 10 spectra were collected of each serum sample using a Horiba Jobin-Yvon LabRAM Raman Spectrometer with a laser of 830 nm. The enhanced Raman bands allowed identifying biomolecules present at low concentration as amide I and III, carotene, glutathione, tryptophan, tyrosine and phenylalanine. Subsequently, the processed SERS spectra were analyzed using multivariate statistical analysis including principal component analysis and linear discriminant analysis (LDA). Preliminary results showed that SERS and PCA-LDA can be used to discriminate between cervical cancer and control samples with high sensitivity and specificity, forming an excellent support technique for current detection techniques.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen En presencia de nanopartículas, la señal Raman se amplifica hasta niveles suficientes como para detectar una molécula individual, por tanto la espectroscopia Surface-Enhanced Raman Scattering (SERS) es actualmente reconocida como una técnica de detección extremadamente sensible con altos niveles de especificidad molecular. Este es el primer reporte en la detección del cáncer cervicouterino basado en la dispersión Raman de superficie amplificada de muestras de suero. Las muestras de suero fueron obtenidas de 14 pacientes quienes fueron clínicamente diagnosticadas con cáncer y 14 voluntarios saludables. Las muestras de suero y nanopartículas de plata de 40 nm en forma coloidal fueron mezcladas usando sonicación. Alrededor de 10 espectros SERS por cada paciente fueron recolectados usando un espectrómetro Raman LabRAM Horiba Jobin-Yvon con un láser de 830 nm. Las bandas Raman fuertemente amplificadas permitieron identificar biomoléculas presentes en bajas concentraciones como amidas I y III, carotenos, glutatión, triptófano, tirosina y fenilalanina. Posteriormente, los espectros SERS procesados fueron analizados utilizando análisis estadístico multivariado incluyendo análisis de componentes principales (PCA) y analisis de discriminante lineal (LDA). Resultados preliminares demostraron que SERS y PCA-LDA pueden ser usados para discriminar entre muestras control y cáncer cervicouterino con alta sensibilidad y especificidad, conformando una excelente técnica de apoyo para las actuales técnicas de detección.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Cervical cancer]]></kwd>
<kwd lng="en"><![CDATA[blood serum]]></kwd>
<kwd lng="en"><![CDATA[surface enhanced Raman scattering]]></kwd>
<kwd lng="en"><![CDATA[principal component analysis]]></kwd>
<kwd lng="en"><![CDATA[linear discriminant analysis]]></kwd>
<kwd lng="es"><![CDATA[Cáncer cervicouterino]]></kwd>
<kwd lng="es"><![CDATA[suero sanguíneo]]></kwd>
<kwd lng="es"><![CDATA[espectroscopia Raman de superficie amplificada]]></kwd>
<kwd lng="es"><![CDATA[análisis de componentes principales]]></kwd>
<kwd lng="es"><![CDATA[análisis de discriminante lineal]]></kwd>
</kwd-group>
</article-meta>
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