0028-3746 0028-3746 S0028-37462021000400286 10.35366/103453 Mexico 00 12 2021 00 12 2021 80 4 286 290 1 Instituto Nacional de Enfermedades Respiratorias 2 1986 3 1992 4 1998 5 2011 139 6 6 1550 6 2021 7 8 9 10 11 2017