<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0028-3746</journal-id>
<journal-title><![CDATA[Neumología y cirugía de tórax]]></journal-title>
<abbrev-journal-title><![CDATA[Neumol. cir. torax]]></abbrev-journal-title>
<issn>0028-3746</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Neumología y Cirugía de Tórax; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas; Sociedad Cubana de Neumología; Sociedad Paraguaya de Neumología; Sociedad Boliviana de Neumología.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0028-37462019000400356</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Descripción clínico-epidemiológica y molecular del cáncer de pulmón en un centro de referencia nacional]]></article-title>
<article-title xml:lang="en"><![CDATA[Clinical-epidemiological and molecular description of lung cancer in a national reference center]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez-Ríos]]></surname>
<given-names><![CDATA[Carla Paola]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Cid]]></surname>
<given-names><![CDATA[Jerónimo Rafael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Barrera]]></surname>
<given-names><![CDATA[Luis Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santillán-Doherty]]></surname>
<given-names><![CDATA[Patricio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alatorre-Alexander]]></surname>
<given-names><![CDATA[Jorge Arturo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>78</volume>
<numero>4</numero>
<fpage>356</fpage>
<lpage>362</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0028-37462019000400356&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0028-37462019000400356&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0028-37462019000400356&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  El cáncer de pulmón es la primera causa de muerte por cáncer a nivel mundial, muestra un incremento en mujeres y en no fumadores en la última década. El progreso en el abordaje diagnóstico-terapéutico se ha logrado gracias al conocimiento de la heterogeneidad tumoral y al análisis molecular.  Material y métodos:  Se analizó la base de pacientes con cáncer de pulmón de enero de 2013 a junio de 2018, con registro de variables sociodemográficas, clínicas y perfil molecular. Resultados expresados mediante medidas de tendencia central y se estimó el odd ratio crudo para mutación de receptor del factor de crecimiento epidérmico y antecedente exposicional y su significancia estadística mediante prueba exacta de Fisher.  Resultados:  Se analizó una cohorte con un total de 751 pacientes. La edad promedio fue de 62.2 años, 53% (n = 398) fueron del género femenino, 51.8% (n = 389) nunca fueron fumadores. Los síntomas más comunes al diagnóstico fueron tos en 87.1% y disnea en 74.4%. El procedimiento broncoscópico fue el método diagnóstico preferido. El estadío clínico IV fue el más frecuentemente reportado. Se encontró 38.19% de cáncer de pulmón de células no pequeñas con receptor del factor de crecimiento epidérmico positivo.  Conclusión:  La situación clínico-epidemiológica del Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas se asemeja a las estadísticas mundiales en diagnóstico y tratamientos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  Lung cancer is the leading cause of cancer death worldwide, showing an increase in women and non-smokers in the last decade. Progress in the diagnostic-therapeutic approach has been achieved thanks to the knowledge of tumor heterogeneity and molecular analysis.  Material and methods:  The base of patients with lung cancer was analyzed from January 2013 to June 2018, with registration of sociodemographic, clinical and molecular profile variables. Results expressed through measures of central tendency and crude odd ratio was estimated for EGFR mutation and exposure antecedent and its statistical significance by Fisher&#8217;s exact test.  Results:  A cohort analyzed from January 2013 to June 2018 with 751 patients. The average age was 62.2 years, 53% (n = 398) were female, 51.8% (n = 389) were never smokers. The most common symptoms were cough in 87.1% and dyspnea in 74.4%. The bronchoscopic procedure was the preferred diagnostic method. Clinical stage IV was the most frequently reported. EGFR was positive in 38.19% of NSCLC.  Conclusion:  The clinical-epidemiological situation of the INER resembles global statistics in both diagnosis and personalized treatments.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cáncer pulmonar]]></kwd>
<kwd lng="es"><![CDATA[no fumadores]]></kwd>
<kwd lng="es"><![CDATA[pronóstico]]></kwd>
<kwd lng="en"><![CDATA[Lung cancer]]></kwd>
<kwd lng="en"><![CDATA[non-smoking]]></kwd>
<kwd lng="en"><![CDATA[prognosis]]></kwd>
</kwd-group>
</article-meta>
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