<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0026-1742</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Fac. Med. (Méx.)]]></abbrev-journal-title>
<issn>0026-1742</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0026-17422016000100045</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Los límites entre la histología y la bioquímica: observando al núcleo celular]]></article-title>
<article-title xml:lang="en"><![CDATA[The boundaries between Histology and Biochemistry: Visualizing the cellular nucleus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas-Lemus]]></surname>
<given-names><![CDATA[Marcela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Milán-Chávez]]></surname>
<given-names><![CDATA[Rebeca]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,UNAM Facultad de Medicina Departamento de Biología Celular y Tisular]]></institution>
<addr-line><![CDATA[D.F. ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,UNAM Facultad de Medicina Departamento de Bioquímica]]></institution>
<addr-line><![CDATA[D.F. ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2016</year>
</pub-date>
<volume>59</volume>
<numero>1</numero>
<fpage>45</fpage>
<lpage>56</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0026-17422016000100045&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0026-17422016000100045&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0026-17422016000100045&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Biología Celular e Histología Médica y Bioquímica son materias básicas que se encuentran en el currículo del estudiante del primer año de medicina. Cada materia aborda aspectos distintos sobre el material genético y sobre el organelo que lo contiene; en Bioquímica se revisan los aspectos metabólicos del ácido desoxirribonucleico (DNA) y en Biología Celular e Histología Médica se estudia al núcleo desde el punto de vista morfológico y tintorial. Aunque es claro que el material genético está contenido dentro del núcleo, para muchos estudiantes esta asociación parece no ser tan obvia, y con el correr del tiempo al médico general se le olvida. Por ello, desde la trinchera de las Ciencias Básicas, consideramos importante establecer la clara asociación entre el núcleo (como se describe en Histología) y la duplicación del material genético (como se revisa en Bioquímica). Se agregó además el concepto de &#8220;micronúcleo&#8221;, que es la evidencia morfológica de fallos durante la duplicación (o la segregación) del material genético durante la división celular, lo que está implicado en procesos de malignización celular. Consideramos pues, que al leer este escrito, los estudiantes podrán analizar al mismo tiempo estos componentes tisulares con &#8220;ojo histológico-bioquímico&#8221;, integrar lo aprendido en ambas asignaturas y establecer relación con los procesos patológicos, mientras al médico general le permitirá &#8220;regresar por las sendas ya visitadas&#8221;.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Cellular Biology and Medical Histology as well Biochemistry are basic courses in the medical curriculum of the first year. Each course - Histology and Biochemistry - deals with different aspects of the genetic material and from the organelle that contains it; Biochemistry reviews the metabolic aspects of DNA while Cellular Biology and Medical Histology studies the nucleus from a morphological point of view. Although it is clear that the genetic material is contained within the nucleus, for many students this association is not obvious, as well as for some general practitioners. Therefore, it is important to consider from the trenches of Basic Sciences, to establish clear association between the nucleus (as described in Histology) and the duplication of genetic material (as it is reviewed in Biochemistry). The concept of &#8220;micronucleus&#8221; is also added because a micronucleus is the morphological evidence of failures during duplication (or segregation) of the genetic material during cell division, which is involved in processes of cell malignancy. Because we believe that by reading this text, students will be able simultaneously to analyze these components with &#8220;histological-biochemical eye&#8221;, integrate the acquired knowledge in both areas and to establish relationships with pathological processes, while the general practitioner would &#8220;return to already visited paths&#8221;.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[núcleo]]></kwd>
<kwd lng="es"><![CDATA[DNA]]></kwd>
<kwd lng="es"><![CDATA[duplicación]]></kwd>
<kwd lng="es"><![CDATA[micronúcleos]]></kwd>
<kwd lng="en"><![CDATA[nucleus]]></kwd>
<kwd lng="en"><![CDATA[DNA]]></kwd>
<kwd lng="en"><![CDATA[duplication]]></kwd>
<kwd lng="en"><![CDATA[micronucleus]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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