<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0016-3813</journal-id>
<journal-title><![CDATA[Gaceta médica de México]]></journal-title>
<abbrev-journal-title><![CDATA[Gac. Méd. Méx]]></abbrev-journal-title>
<issn>0016-3813</issn>
<publisher>
<publisher-name><![CDATA[Academia Nacional de Medicina de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0016-38132023000300261</article-id>
<article-id pub-id-type="doi">10.24875/gmm.m23000749</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Mecanismos y dianas terapéuticas del inflamasoma NLRP3 en la miocardiopatía diabética]]></article-title>
<article-title xml:lang="en"><![CDATA[NLRP3 inflammasome mechanism and therapeutic targets in diabetic cardiomyopathy]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[Qing]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guo]]></surname>
<given-names><![CDATA[Wenxiu]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Yue]]></surname>
<given-names><![CDATA[Tun]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Lu]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mou]]></surname>
<given-names><![CDATA[Huaming]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,North Sichuan Medical College Escuela de Medicina Clínica ]]></institution>
<addr-line><![CDATA[Nanchong ]]></addr-line>
<country>China</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Chongqing University Three Gorges Hospital Departamento de Gastroenterología ]]></institution>
<addr-line><![CDATA[Chongqing ]]></addr-line>
<country>China</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Chongqing University Three Gorges Hospital Departamento de Endocrinología ]]></institution>
<addr-line><![CDATA[Chongqing ]]></addr-line>
<country>China</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Chongqing University Three Gorges Hospital Departamento Cardiovascular ]]></institution>
<addr-line><![CDATA[Chongqing ]]></addr-line>
<country>China</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<volume>159</volume>
<numero>3</numero>
<fpage>261</fpage>
<lpage>267</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0016-38132023000300261&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0016-38132023000300261&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0016-38132023000300261&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La cardiomiopatía diabética es una complicación grave de la diabetes causada por estrés oxidativo, inflamación, resistencia a la insulina, fibrosis miocárdica y lipotoxicidad. Se trata de un padecimiento insidioso, complejo y difícil de tratar. El inflamasoma NLRP3 desencadena la maduración y liberación de citoquinas proinflamatorias, participa en procesos fisiopatológicos como la resistencia a la insulina y la fibrosis miocárdica, además de estar estrechamente relacionado con la aparición y progresión de la cardiomiopatía diabética. El desarrollo de inhibidores dirigidos a aspectos específicos de la inflamación sugiere que el inflamasoma NLRP3 puede utilizarse para tratar la cardiomiopatía diabética. Este artículo pretende resumir el mecanismo y las dianas terapéuticas del inflamasoma NLRP3 en la cardiomiopatía diabética, así como aportar nuevas sugerencias para el tratamiento de esta enfermedad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Diabetic cardiomyopathy (DCM) is a serious complication of diabetes caused by oxidative stress, inflammation, insulin resistance, myocardial fibrosis, and lipotoxicity; its nature is insidious, complex and difficult to treat. NLRP3 inflammasome triggers the maturation and release of pro-inflammatory cytokines, participates in pathophysiological processes such as insulin resistance and myocardial fibrosis, in addition to being closely related to the development and progression of diabetic cardiomyopathy. The development of inhibitors targeting specific aspects of inflammation suggests that NLRP3 inflammasome can be used to treat diabetic cardiomyopathy. This paper aims to summarize NLRP3 inflammasome mechanism and therapeutic targets in diabetic cardiomyopathy, and to provide new suggestions for the treatment of this disease.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cardiomiopatía diabética]]></kwd>
<kwd lng="es"><![CDATA[Citoquinas proinflamatorias]]></kwd>
<kwd lng="es"><![CDATA[Inflamasoma NLRP3]]></kwd>
<kwd lng="en"><![CDATA[Diabetic cardiomyopathy]]></kwd>
<kwd lng="en"><![CDATA[Pro-inflammatory cytokines]]></kwd>
<kwd lng="en"><![CDATA[NLRP3 inflammasome]]></kwd>
</kwd-group>
</article-meta>
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