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Acta ortopédica mexicana

versión impresa ISSN 2306-4102

Acta ortop. mex vol.32 no.1 México ene./feb. 2018

 

Original articles

Treatment algorithm for Charcot foot and surgical technique with circular external fixation

Algoritmo de tratamiento para el pie de Charcot y técnica quirúrgica con fijación externa circular

JM Rios-Ruh1  * 

X Martin-Oliva2 

A Santamaría-Fumas1 

A Domínguez-Sevilla1 

L López-Capdevila1 

J Vilà y Rico3 

JM Sales-Pérez1 

1 Orthopaedic Surgeon, Department of Orthopaedics. Consorci Sanitari Integral. Barcelona, Spain.

2 Anatomy Department, Universidad de Barcelona, Spain.

3 Orthopaedic Surgeon, Department of Orthopaedics. Hospital El Remei, Spain.

Abstract:

Background:

Charcot neuroarthropathy (CNA), commonly known as Charcot foot, is one of the most debilitating complications of diabetes mellitus. Patients with plantar ulcer and osteomyelitis (OM) due to Charcot foot represent a high cost for health systems and society in general. The amputation risk for ulcerated Charcot patients is 12 times higher than general population under 65 years old.

Material and methods:

In this article we present the CNA treatment protocol we use in our center. We also make a detailed description of the surgical technique «single stage surgery» with circular external fixation.

Results:

Our CNA treatment protocol covers the most common presentations of this severe neuropathic complication. With the «single stage surgery» using circular external fixation we achieve an ulcer-free foot, successful treatment of the OM, correction of the deformity, diminished the cost of treatment, avoided amputation and prevented recurrence of the ulcer.

Conclusions:

The use of a treatment algorithm based on the current literature, can be an invaluable tool in the treatment of these complex patients. The circular external fixation has proven to be the only reliable tool for treating complex Charcot foot in the context of poor bone stock, active ulcers, soft tissues problems and OM.

Key words: Charcot neuroarthropathy; diabetes; algorithm; static circular fixation; osteomyelitis; ulcer

Resumen:

Antecedentes:

La neuroartropatía de Charcot, comúnmente llamado «pie de Charcot», es una de las complicaciones más incapacitantes de la diabetes mellitus. Los pacientes con úlceras plantares y osteomielitis representan un gasto elevado para los diferentes sistemas de salud y la sociedad en general. El riesgo de amputación en estos pacientes es 12 veces más elevado que en la población general menor de 65 años.

Material y métodos:

En el presente trabajo mostramos el algoritmo de tratamiento de nuestro centro y también presentamos de manera detallada la técnica quirúrgica de un solo tiempo con fijación externa circular.

Resultados:

Nuestro algoritmo de tratamiento cubre la mayor parte de las presentaciones clínicas de esta complicación. Con la cirugía en un solo tiempo y el uso de la fijación externa circular se ha logrado desaparecer las úlceras, tratar satisfactoriamente la osteomielitis, corregir la deformidad, disminuir costos, prevenir recurrencias y evitar las amputaciones.

Conclusiones:

El uso de un algoritmo de tratamiento basado en la literatura actual es de suma utilidad para este grupo de pacientes. La fijación externa circular ha demostrado ser una herramienta confiable en el tratamiento integral de estos casos.

Palabras clave: Neuroartropatía de Charcot; diabetes; algoritmo; fijación circular estática; osteomielitis; úlceras

Background

Diabetes mellitus (DM) world prevalence ranges from 4 to 6.5%, with an exponential increase in the last decade.1 Spain does not escape this reality; the prevalence of diabetes in our country is 13.8%, with almost 6% ignoring they have this serious disease.2

The World Health Organization (WHO) calls diabetes the epidemic of the 21st century.2 DM complications cause a major impact on health and quality of life of patients, with an elevated cost to health systems and society around the world.3

One of the most debilitating complications of diabetes mellitus is Charcot neuroarthropathy (CNA). Defined as an inflammatory condition, affects the foot and ankle with varying degrees of bone destruction and deformity, the most classic one known as «rocker bottom» deformity4 (Figure 1).

Figure 1: «Rocker Bottom» deformity. 

The diagnosis of CNA in the active phase can be done clinically, confirming the presence of distal neuropathy accompanied by a swollen, red and painful foot.5,6 In the non-active phases of CNA structured foot and ankle deformities increase by 7 times the possibility of amputation in these population, and 12 times when there is an ulcer.7

Eichenholtz classification8 is used to define Charcot foot clinical stages. Brodsky9 classification, in the other hand, allows us to locate the lesion anatomically, midfoot being the most commonly affected area. Recent literature states that existing clinical classifications do not provide a clear pathway for treatment decision and proposes a simpler classification using the terms active and non-active Charcot.4

The goal of CNA treatment, both orthopedic and surgical, is to obtain an ulcer free, stable plantigrade foot, without OM and able to ambulate.10 Achieving these goals notably reduces the rate of amputations.11

Some studies suggest that radiological measures may predict the development of ulcers; Wukich12 defined a limit of 27 degrees of alteration Meary’s line in the lateral X-ray of the foot as a predictor of ulcers.

Classically, surgical treatment was reserved for patients in whom the orthopedic treatment had failed;13 recent publications suggest that in selected patients, early surgical treatment may offer a good option achieving correction and stabilization of the deformity.14

Due to the poor bone quality of these patients, Sammarco15 proposed the «superconstructs» concept, applying large diameter hardware across non affected joints, acting as a frame.

Pinzur16 proposes the «single stage surgery» that can treat both bone and soft tissue infection, and correct foot deformity through a system of circular static fixation. With external fixation techniques, authors have managed to avoid amputation in the majority of their patients.17

Material and methods

In our foot and ankle unit the treatment of CNA follows a protocol (Table 1); according to this treatment algorithm, patients with plantigrade stable foot are treated conservatively with adequate footwear and adapted insoles if Charcot foot is in the non-active phase. In the active phase, the total contact cast (TCC) or diabetic specific walker boots should be used.

Table 1: Charcot neuroarthropathy treatment protocol used in our center. 

Plantigrade foot. Active Total contact cast
Plantigrade foot. Non active Adequate footwear and adapted insoles
Non-plantigrade foot. No history of ulcers and OM, good soft tissues and good bone stock Internal fixation «superconstruct»
Non-plantigrade foot. History or presence of ulcers and OM, bad soft tissues and poor bone stock «Single stage surgery» with circular external fixation
Failed internal fixation «Single stage surgery» with circular external fixation

Meanwhile, non-plantigrade patients are treated surgically if they don’t respond to orthopedic measures. If there is no presence or history of ulcers and OM, good soft tissues and good bone stock, internal fixation using superconstructs may be a treatment option. But we must admit that patients with these characteristics are difficult to find in our area.

When there is poor bone stock, soft tissue compromise, an active ulcer and bone infection or recent history of it, we do a «single stage surgery» with circular external fixation.

Surgical treatment in our center is performed, using the «single stage surgery» technique with the circular external fixator that we learned directly from Dr. Michael Pinzur at Loyola University Medical Center in Chicago.

Surgical technique: We use the circular external fixator Distraction Osteogenesis Ring static System® (DePuy Synthes). We proceed to describe the surgical technique for midfoot Charcot, even though it can be used for the lesser common hindfoot Charcot. After spinal or regional anesthesia, the contralateral foot is protected to prevent decubitus injuries during surgery. The tourniquet is placed at thigh level and used only during the first half of the surgery, being released before applying the fixator. The patient is supine; sterile surgical drapes, that include the entire limb, are used.

Step 1. Correction of the equinus deformity: Percutaneous tenotomy of the Achilles tendon, through three incisions allows the hindfoot to return to a more physiological position (Figure 2). If during the preoperative planning equinus deformity is believed to be caused by gastrocnemius shortening we use the Strayer technique to address it.

Figure 2: Tenotomy of the Achilles tendon. 

Step 2. Remodeling osteotomy and infected tissue resection: According to the anatomical location of the deformity apex in the midfoot, and the presence of abduction or adduction deformity, we use a medial or lateral approach to perform the osteotomy, which is extended without a doubt if there is risk of compromising the skin during the procedure. In some complex cases, we have found a double approach to be more comfortable. Subperiosteal plane dissection around the entire circumference of the midfoot creates a safe working space that preserves tendons and neurovascular elements of the area. Adequate exposure is achieved using Hohmann elevators (Figure 3).

Figure 3: Safe working space in the midfoot. 

Preoperative planning determines the shape and size of the necessary osteotomy in order to achieve the ultimate goal, a plantigrade foot with proper alignment and resection of the infected tissue. This bone resection relaxes the soft tissues (by reduction of the total length of the foot) and contributes to the healing of existing ulcers.

Once the bone wedge has been resected we proceed to temporary fixation with two 3 mm diameter Steinman pins. They are introduced through the dorsum of the foot toward the plantar hindfoot avoiding the dorsal neurovascular bundle. The image intensifier controls the correct position of the foot and the lack of plantar bony prominences.

Step 3. Ulcer excision: If there is a plantar ulcer it should be excised and submitted for microbiological study. There is an option of closing the plantar area with separated nonabsorbable sutures without excessive skin tension. If closing sutures are not possible, it is advisable to close by secondary intention with or without negative pressure systems.

Step 4. Applying the circular frame: The circular static fixator is applied to the patient with 1.8 mm reduction wires. We use two wires on the calcaneus with a 30 degrees angle between each other (Figure 4). The structure at risk here is the retromalleolar medial neurovascular bundle. Once the hindfoot is set, one wire should be applied distal to the arthrodesis area in the midfoot. This last wire is fixed just behind its ideal place, this will focus compression in the arthrodesis area once we apply tension to it.

Figure 4: Two wires through the calcaneus. 

Subsequently, two wires will be positioned in each of the two tibial rings, with a 30 degree angle between them. If the area to compress is the ankle we can do it simply by descending the distal ring to the foot plate. It is essential to know precisely the anatomical arrangement of the neurovascular elements in each level of placement of the transfixing wires.

Step 5. Postoperative protocol: Usually, patients start partial weight bearing at 48-72 hours after surgery (Figure 5). Wound and pin site care are done as usual. The patient is discharged from the hospital 48-72 hours after surgery. Follow-up visits and X-rays are done every two to three weeks. Frame removal is performed at 8-12 weeks depending on clinical and X-ray evolution. After removal of the frame, a weight-bearing total contact cast (TCC) is used 4 to 6 weeks. After this, they make a transition to diabetic footwear with adequate insoles. These patients should be followed monthly by trained personnel to prevent recurrence of active Charcot or new ulcerations.

Figure 5: Early weight bearing. 

Results

According to our protocol and the use of the circular external fixator we are able to obtain an ulcer-free foot, successful treatment of the OM, correction of the deformity, avoided amputation and prevented recurrence of the ulcer in all our patients. Some complications may arise; superficial infection at pin entrance that is solved with local wound care and, a couple of broken wires that did not need to be replaced.

Discussion

Most Charcot foot injuries can be treated orthopedically.4 The most recently published treatment guide by the International Working Group of Diabetic Foot (IWGDF)18 recommends the use of TCC as the treatment of choice in acute NCA until clinical stabilization, which coincides with our treatment algorithm.

We must avoid amputation at all cost because literature clearly shows that mortality of diabetic patients 5 years after amputation is as high as 60%, being in some cases superior to some types of cancer.19 In some patients, the classical internal fixation techniques may be doomed to failure, due to the poor bone quality, secondary to vitamin D deficiency related osteoporosis, that characterizes diabetic patients.20 Another factor to take into account is that this patient population is prone to pseudarthrosis,21 which applies to the osteosynthesis material to continuous mechanical stress with a high risk of rupture and failure.

In cases of Charcot foot with suspected osteomyelitis and or presence of a plantar ulcer, resection of infected bone with static circular external fixation, with specific antibiotic treatment, guided by microbiological culture, is the best choice of treatment and there are multiple studies that support this technique in these situations.11,13,16,22,23,24

Until now our results regarding cure rate of plantar ulcers, correction of deformity, osteomyelitis eradication and recurrence of injury is consistent with the results obtained by other authors.16,17

There are publications that propose the treatment of Charcot foot with hybrid external fixation systems using classic pins.25 Its disadvantage is the risk of fractures in the site of insertion of the classic big pins24 in diabetic patients with very poor bone quality.

Rogers et al26 refers complications of using static circular fixation systems are frequent but of little clinical relevance. The most common, with an incidence between 10 and 20%, is the superficial infection of pin site that satisfactorily resolves with local treatment or may need oral antibiotic therapy. In our series, the management and prognosis of superficial infection at this level does not vary from the published data.26

Other complications related to ischemia time as compressive neurapraxia, deep vein thrombosis, skin necrosis and wound infection26,27 were not present in our series. The fact that we only use ischemia for the first half of the surgery may play a role in the latest.

For all previous reasons we firmly believe that external circular static fixation is one of the most ad-vantageous treatment options for complex Charcot foot. It has some clear benefits when compared to classic internal fixation in these patients (Table 2). That is why we decided to adopt this technique as treatment of choice in our center.

Table 2: Benefits of circular external fixation compared to classic internal fixation. 

Circular external fixation Internal fixation
Requires ample surgical dissection No
Yes
Tolerates osteomyelitis Yes No
Immediate weight bearing Yes No
Risk of peri-implant fracture No Yes
Requires good bone stock No Yes
Pseudarthrosis may affect fixation system No Yes
Need for removal of osteosynthesis material No May be necesary

Charcot foot is a very complex disease, not only because of the injury itself but because of characteristics inherent to the host in whom it develops. The objectives of the orthopedic surgeon must be to provide an adequate and patient-tailored treatment. The correct assessment of the patient in multidisciplinary diabetic foot units and a strict compliance with treatment protocols, will allow us to give each patient the opportunity to prevent a major amputation.

The weight bearing total-contact cast in acute CNA and superconstructs in very selected patients are literature based valid treatment options contemplated within the algorithm that we use in our center. «Single stage surgery» with circular external fixator will be a useful technique for treating cases of complex Charcot foot with poor bone stock, soft tissue compromise, an active ulcer or bone infection or recent history of it. The use of economic resources for treating these patients after surgery have been significantly lower after «single stage surgery», which is an important fact for deciding treatment of choice nowadays.

«Compliance with ethical standards»

  • Conflict of interest: The authors declare that they have no conflict of interest.

  • Funding: There is no funding source.

  • Ethical approval: This article does not contain any studies with human participants or animals performed by any of the authors.

  • Informed consent: Informed consent was obtained from all individual participants included in the study.

References

1. Batista F, Magalhães AA, Gamba M, Nery C, Cardoso C: Ten years of a multidiscipli-nary diabetic foot team approach in Sao Paulo, Brazil. Diabetic Foot Ankle. 2010; 1. [ Links ]

2. Soriguer F, Goday A, Bosch-Comas A, Bordiú E, Calle-Pascual A, Carmena R, et al: Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the Di@bet.es Study. Diabetologia. 2012; 55(1): 88-93. [ Links ]

3. Global report on diabetes. World Health Organization. [Consulted 02-07-2016]. Available in: http://www.who.int/diabetes/global-reportLinks ]

4. Rogers LC, Frykberg RG, Armstrong DG, Boulton AJ, Edmonds M, Van GH, et al: The Charcot foot in diabetes. Diabetes Care. 2011; 34(9): 2123-9. [ Links ]

5. Armstrong DG, Todd WF, Lavery LA, Harkless LB, Bushman TR. The natural history of acute Char-cot’s arthropathy in a diabetic foot specialty clinic. J Am Podiatr Med Assoc. 1997; 87(6): 272-8. [ Links ]

6. Trepman E, Nihal A, Pinzur MS: Current topics review: Charcot neuroarthropathy of the foot and ankle. Foot Ankle Int. 2005; 26(1): 46-63. [ Links ]

7. Sohn MW, Stuck RM, Pinzur MS, Lee TA, Budiman-Mak E: Lower-extremity amputation risk after Charcot arthropathy and diabetic foot ulcer. Diabetes Care. 2010; 33(1): 98-100. doi: 10.2337/dc09-1497. Epub 2009 Oct 13. [ Links ]

8. Eichenholtz SN. Charcot Joints. Springfield, IL, USA: Charles C. Thomas; 1966. [ Links ]

9. Brodsky JW. Management of Charcot joints of the foot and ankle in diabetes. Semin Arthroplasty. 1992; 3: 58-62. [ Links ]

10. Pinzur M: Surgical versus accommodative treatment for Charcot arthropathy of the midfoot. Foot Ankle Int. 2004; 25(8): 545-9. [ Links ]

11. Schneekloth BJ, Lowery NJ, Wukich DK: Charcot neuroarthropathy in patients with diabetes: an up-dated systematic review of surgical management. J Foot Ankle Surg. 2016; 55(3): 586-90. [ Links ]

12. Wukich DK, Raspovic KM, Hobizal KB, Rosario B: Radiographic analysis of diabetic midfoot Charcot neuroarthropathy with and without midfoot ulceration. Foot Ankle Int. 2014; 35(11): 1108-15. [ Links ]

13. Yousry AH, Abdalhady AM: Management of diabetic neuropathic ankle arthropathy by arthrodesis using an Ilizarov frame. Acta Orthop Belg. 2010; 76(6): 821-6. [ Links ]

14. Williams MO: Long-term cost comparison of major limb salvage using the Ilizarov method versus amputation. Clin Orthop Related Res. 1994; 301: 156-8. [ Links ]

15. Sammarco VJ, Sammarco GJ, Walker EW, Guiao RP: Midtarsal arthrodesis in the treatment of Charcot midfoot arthropathy. J Bone Joint Surg. 2009; 91(1): 80-91. [ Links ]

16. Pinzur MS, Gil J, Belmares J: Treatment of osteomyelitis in Charcot foot with single-stage resection of infection, correction of deformity, and maintenance with ring fixation. Foot Ankle Int. 2012; 33(12): 1069-74. [ Links ]

17. Conway JD: Charcot salvage of the foot and ankle using external fixation. Foot Ankle Int. 2008; 13(1): 157-73. [ Links ]

18. Schaper NC, Van Netten JJ, Apelqvist J, Lipsky BA, Bakker K; International Working Group on the Diabetic Foot (IWGDF). Prevention and management of foot problems in diabetes: a Summary Guidance for Daily Practice 2015, based on the IWGDF Guidance Documents. Diabetes Res Clin Pract. 2017; 124: 84-92. [ Links ]

19. Armstrong DG, Wrobel J, Robbins JM: Guest editorial: are diabetes-related wounds and amputations worse than cancer. Int Wound J. 2007; 4(4): 286-7. [ Links ]

20. Yoho RM, Frerichs J, Dodson NB, Greenhagen R, Geletta S: A comparison of vitamin D levels in nondiabetic and diabetic patient populations. J Am Podiatr Med Assoc. 2009; 99(1): 35-41. [ Links ]

21. Cozen L: Does diabetes delay fracture healing? Clin Orthop Rel Res. 1972; 82: 134-40. [ Links ]

22. Gil J, Schiff AP, Pinzur MS: Cost comparison limb salvage versus amputation in diabetic patients with Charcot foot. Foot Ankle Int. 2013; 34(8): 1097-9. [ Links ]

23. Pinzur MS: Surgical treatment of the Charcot foot. Diabetes Metab Res Rev. 2016; 32(S1): 287-91. [ Links ]

24. Jones CP, Youngblood CS, Waldrop N, Davis WH, Pinzur MS: Tibial stress fracture secondary to half-pins in circular ring external fixation for Charcot foot. Foot Ankle Int. 2014; 35(6): 572-7. [ Links ]

25. Dalla Paola L, Ceccacci T, Ninkovic S, Sorgentone S, Marinescu MG: Limb salvage in Charcot foot and ankle osteomyelitis: combined use single stage/double stage of arthrodesis and external fixation. Foot Ankle Int. 2009; 30(11): 1065-70. [ Links ]

26. Rogers LC, Bevilacqua NJ, Frykberg RG, Armstrong DG: Predictors of postoperative complications of Ilizarov external ring fixators in the foot and ankle. J Foot Ankle Surg. 2007; 46(5): 372-5. [ Links ]

27. El-Moatasem EHM, El-Ghazaly S: Diabetic neuropathic foot and ankle instability: early mini-incision closed fusion using the Ilizarov ring fixator. A pilot study. Current Orthopaedic Practice. 2016; 27(1): 77-83. [ Links ]

Level of evidence: III

*Corresponding author: Juan Manuel Rios Ruh. Nápoles No. 303, 1-1. Barcelona, España. Zip code 08025. Telephone: +34 616848998. E-mail: tupieytobillo@gmail.com

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