Services on Demand
Journal
Article
text new page (beta)
Spanish (pdf)
Article in xml format
Article references
Automatic translation
Send this article by e-mailIndicators
-
Cited by SciELO -
Access statistics
Related links
-
Similars in
SciELO
Share
Permalink
Revista odontológica mexicana
Print version ISSN 1870-199X
Rev. Odont. Mex vol.10 n.1 Ciudad de México Mar. 2006
https://doi.org/10.22201/fo.1870199xp.2006.10.1.15929
Trabajos originales
Mixoma odontogénico; expresión y localización espacial de la fibronectina, vitronectina y queratina
Odontogenic mixoma; expression and spacial localization of the fibronectin, vitronectin and keratin
* Prof. de Cirugía Bucal y Maxilofacial de la División de Estudios Profesionales de la Facultad de Odontología, UNAM. México.
§ Jefe del Departamento de Biología Celular, de la División de Estudios de Posgrado. Facultad de Odontología, UNAM. México.
El mixoma odontogénico es una neoplasia benigna de baja prevalencia, que ocurre en los maxilares, normalmente asociado a dientes no erupcionados o ausentes. El objetivo de este trabajo fue determinar cualitativamente el grado de expresión de los anticuerpos, vitronectina, fibronectina y queratina, de las lesiones con el diagnóstico histopatológico de mixomas odontogénicos y el folículo dental humano. Se seleccionaron los expedientes del Laboratorio de Patología Experimental de la División de Estudios de Posgrado e Investigación de la Facultad de Odontología (UNAM), en un periodo de 14 años, localizando 20 cubos con el diagnóstico de mixoma odontogénico y 2 cubos de folículo dental humano como control. Se realizó la técnica de inmunohistoquímica indirecta para determinar la presencia de estas proteínas. La inmunolocalización reveló una intensa expresión de fibronectina (85%) y vitronectina (90%), asociada al estroma de la neoplasia y estructuras celulares así como al porcentaje de expresión de queratina (55%).
Palabras clave: Mixoma odontogénico; vitronectina; fibronectina y queratina
Odontogenic myxoma is a low prevalence, benign neoplasia occurring in the maxillae normally associated with teeth which have not come through or which were never present. The objective of this study was to determine the presence of antibodies, vitronectin, fibronectin and keratin in the extra-cellular matrix of odontogenic myxoma and dental follicles. The files of the experimental Pathology Laboratory of the postgraduate and Research Division of the School of Dentistry at UNAM, over a period of 14 years, were studied, and 20 specimens of odontogenic myxoma and 2 of human dental follicles, as control, were found for processing using histomorphological analysis. Immunolocation revealed intense presence of fibronectin and vitronectin associated with the stroma of the tumour and cellular structures. It should be noted that a high percentage of the lesions studied showed keratin.
Key words: Odontogenic myxoma; vitronectin; fibronectin; keratin
Referencias
1. Gorlin RJ, Goldman HM. Thoma Patología Oral. Edición. Barcelona. Editorial Salvat 1980: 548-549. [ Links ]
2. Shafer W, Hine M, Levy B. Tratado de Patología Bucal. 4ª Edición. México. Editorial Interamericana 1988: 300-301. [ Links ]
3. Robbins SL. Tratado de Patología. 3ª Edición. México 1968: 713. [ Links ]
4. Slootweg PJ, Van Den Bos T, Straks W et al. Glycosaminoglycans in myxoma of the jaw: a biochemical study. J Oral Pathology 1985; 14: 299-306. [ Links ]
5. Kramer IRH, Pindborg JJ, Shear DM et al. Histological typing of odontogenic tumours. 2nd ed. Berlin: Springer-Verlag; 1992: 23. [ Links ]
6. Schmidt-Westhausen A, Becker J, Schuppan D, Burkhardt A, Reichart PA et al. Odontogenic myxoma-characterization of the Extracellular Matrix (ECM) of the tumour stroma. Oral Oncol, Eur J Cancer 1994; 30: 377-380. [ Links ]
7. Sánchez-Torres J, Ovalle WJ et al. Mixoma odontogénico en rama ascendente mandibular. Revisión bibliográfica e informe de un caso clínico. Gaceta Médica de México 1990; 11: 405-411. [ Links ]
8. Gordon WB et al. Large odontogenic myxoma of the mandible treated by sagital ramus osteotomy and peripheral Osteotomy. J Oral Maxillofac Surg 1992; 50: 1221-1224. [ Links ]
9. Cuesta-Carnero R, Bachur RO, Gendelman H et al. Odontogenic myxoma: report of a case. J Oral Maxillofac Surg 1988; 46: 705-709. [ Links ]
10. Kimura A, Hasegara H, Satou K, Kitamura Y et al. Odontogenic myxoma showing active epithelial islands UIT microcystic features. J Oral Maxillofac Surg 2001; 59: 1226-1228. [ Links ]
11. Ward TO, Rooney G et al. Asymptomatic expansion of the mandible. JADA 1989; 119: 169-170. [ Links ]
12. Lombardi T, Kaffer R, Bernand J-P, Fiore-Donno G, Samson J et al. Immunohistochemical staining for vimentin filaments and S-100 protein in myxoma of the jaws. J Oral Pathol 1988; 17: 175-177. [ Links ]
13. Leiberman A, Forte V, Thorner P et al. Maxillary myxoma in children. Int J Pediatr ORL 1990; 18: 277-284. [ Links ]
14. Keszler A, Dominguez F et al. Myxoma in childhood: An analysis of 10 cases. J Oral Maxillofac Surg 1988; 53: 518-521. [ Links ]
15. Hendler BH, Abaza NA, Quinn P et al. Odontogenic myxoma. Surgical management and an ultrastructural study. Oral Surg, Oral Med, Oral Pathol 1979; 47: 203-217. [ Links ]
16. Moshiri S, Oda D, Worthington P, Myall R et al. Odontogenic myxoma: histochemical and ultrastructural study. J Oral Pathol Med 1992; 21: 401-403. [ Links ]
17. Peltola J, Magnusson B, Happonen RP, Borrman H et al. Odontogenic myxoma a radiographic study of 21 tumors. Br J Oral Maxillofac Surg 1994; 32: 298-302. [ Links ]
18. De la Piedra M, Ledesma-Montes C et al. Mixoma odontogénico revisión de la literatura y presentación de dos casos. Práctica Odontológica 1990; 11: 42-45. [ Links ]
19. Chuchurru JA, Luberti R, Cornicelli JC, Dominguez F V et al. Myxoma of the mandible with unusual radiographic appearance. J Oral Maxillofac Surg 1985; 43: 987-990. [ Links ]
20. Takahashi H, Fujita S, Okabe H et al. Immunohistochemical investigation in odontogenic myxoma. J Oral Pathol Med 1991; 20: 114-119. [ Links ]
21. Auriol M, Chomette G, Martino R, Bertrand JC, Gulbert F et al. Myxome odontegene; Etude histoenzymologique et ultrastructurale; a propos de 5 observations. J Biol Buccale 1986; 14: 215-222. [ Links ]
22. Muzio LL, Nocini P, Favia G, Procaccini M, Mignogna MD et al. Odontogenic myxoma of the jaws. A clinical, radiologic, immunohistochemical and ultrastructural study. Oral Surg, Oral Med, Oral Pathol, Oral Radiol Endod 1996; 82: 426-433. [ Links ]
23. Jaeger M, Santos J, Domingues M, Ruano R, Araújo N, Caroli A, Jaeger R et al. A novel cell line that retains the morphological characteristics of the cells and matrix of odontogenic myxoma. J Oral Pathol Med 2000; 29: 129-38. [ Links ]
24. Schvartz I, Seger D, Shaltiel S et al. Vitronectin. IJBCB 1999; 31: 539-544. [ Links ]
25. O’Toole E A et al. Extracellular matrix and kerinocyte migration. Clin Exp Dermatol 2001; 26: 525-530. [ Links ]
26. Carlucci P, Fioroni M, Rubini C et al. Bel-2 p53 and Mb-1 in odontogenic myxoma. J Dent Res 1999; 78: 522. [ Links ]
27. Armstrong PB, Armstrong MT et al. Intercellular invasion and the organizational stability of tissues: a role for fibronectin. Biochimica et Biophysica Acta 2000; 1470: 09-020. [ Links ]
28. Danen EH, Yamada KM et al. Fibronectin, integrins, and growth control. J Cell Physiol 2001; 189: 1-13. [ Links ]
Este es un artículo publicado en acceso abierto bajo una licencia Creative Commons
