Revisiones

 

Trends in bioseparations

 

Tendencias en bioseparaciones

 

J. González-Valdez^†, K. Mayolo-Deloisa^†, M. González-González^†, M. Rito-Palomares*

 

Centro de Biotecnología FEMSA, Tecnológico de Monterrey, Campus Monterrey, Ave. Eugenio Garza Sada 2501 Sur, Monterrey, NL, 64849, México. *Corresponding author. E-mail: mrito@itesm.mx Tel. +52 81 8328-4132; Fax +52 81 8328-4136.

 

Received June 14, 2013;
Accepted November 4, 2013.

 

Abstract

The biotechnology industry is changing every day to improve the purity, yield and throughput of products, besides becoming more effcient while using fewer resources. In this sense, this short review aims to present a general overview of the trends in bioseparations that will be met in the bioprocessing area of biotechnology in order to continue overcoming these challenges. It is identified that these tendencies will impact the following stages of the bioseparation train: product sources, primary recovery and purification. New approaches involving process integration, intensification and automation, microscaling and greener practices are addressed. Biotechnological processes will continue to evolve becoming the spearhead of process development, targeting products that will benefit lifestyle and improve quality of life. Nonetheless, the aspects that are covered in this work are up to day the state of the art in this constant change and will undeniably have important repercussions in the future of this area.

Keywords: bioseparations, primary recovery, purification, microscale devices, green bioprocesses.

 

Resumen

La industria biotecnológica cambia todos los días para mejorar la pureza, el rendimiento y la recuperación de productos; además de hacerse más eficiente optimizando el uso de recursos. En este sentido, esta corta revisión busca presentar un panorama general de las tendencias en bioseparaciones que deben ocurrir en el área de bioprocesos para seguir alcanzando estos retos. Se ha identificado que las etapas del tren de bioseparaciones que serán impactadas son: las fuentes de materia prima, las etapas de recuperación primaria y la de purificación. Los nuevos enfoques que serán utilizados incluyen la integración y automatización de procesos, el microescalamiento y prácticas amigables con el medio ambiente. Los procesos biotecnológicos seguirán evolucionando para convertirse en la punta de lanza del desarrollo de nuevos productos que mejorarán el estilo y la calidad de vida. No obstante, los aspectos que se cubren en este trabajo son hasta ahora el estado del arte de este cambio que sin duda alguna tendrán una repercusión importante en el futuro cercano del área.

Palabras clave: bioseparaciones, recuperación primaria, purificación, micro dispositivos, procesos verdes.

 

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Acknowledgments

The authors wish to thank the Bioprocess Research grant chair at Instituto Tecnológico y de Estudios Superiores de Monterrey (CAT-161) for its support.

 

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Nota

† The authors contributed equally to this work.