Revisiones

 

Nanobiotechnology for medical diagnostics

 

Nanobiotecnología para el diagnóstico médico

 

K. Kourentzi¹ and R. C. Willson^1,2,3,4*

 

¹ Department of Chemical & Biomolecular Engineering, University of Houston, Houston, TX 77204, USA.

² Department of Biology & Biochemistry, University of Houston, Houston, TX 77004, USA.

³ Houston Methodist Research Institute, Houston, TX, 77030, USA.

⁴ Centro de Biotecnología FEMSA, Departamento de Biotecnología e Ingeniería de Alimentos, Tecnológico de Monterrey, Monterrey, NL 64849, Mexico. *Corresponding author. E-mail: willson@uh.edu, +1-713-743-4308.

 

Received June 14, 2013.
Accepted December 31, 2013.

 

Abstract

Traditional core areas of chemical engineering education are being extended by new expertise in science and engineering at the molecular and nanometer scale. Chemical engineers have been pursuing a dynamic role in the design and development of new generations of diagnostic platforms exploiting different nanomaterials and "are the forefront of this rapidly developing field, with the potential to propel discoveries from the bench to bedside" (Ruan et al., 2012).

Nanobiotechnology leverages existing expertise from engineering and biology, promotes interdisciplinary discoveries and addresses key elements of next-generation clinical applications.

In the present review we attempt to give an overview of the latest technologies that in our opinion hold great promise as the basis of powerful biodiagnostic tools.

Keywords: bioassays, ELISA, Immuno-PCR, phage, nanofabrication.

 

Resumen

Las áreas tradicionales de la educación en ingeniería química están siendo extendidas por nuevas experiencias en ciencia e ingeniería a escalas molecular y nanométrica. Los ingenieros químicos han estado persiguiendo jugar un rol dinámico en el diseño y desarrollo de nuevas generaciones de plataformas de diagnóstico explotando diferentes nanomateriales y "son el frente de este campo que se encuentra rápidamente en desarrollo, con el potencial de impulsar descubrimientos que vayan desde el laboratorio hasta el tratamiento de pacientes." (Ruan et al., 2012).

La nanobiotecnología sirve como palanca en la experiencia que se tiene en ingeniería y biología, promueve descubrimientos interdisciplinarios y atiende elementos clave de la siguiente generación de aplicaciones clínicas.

En la presente revisión tratamos de proporcionar un visión general de las últimas tecnologías que en nuestra opinión constituyen una gran promesa como base para herramientas poderosas de diagnóstico.

Palabras clave: bioensayos, ELISA, Inmuno-PCR, fago, nanofabricación.

 

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Acknowledgments

RCW acknowledges the Robert A. Welch Foundation for support under grant E-1264, and the Huffington-Woestemeyer Professorship.

 

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