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Boletín médico del Hospital Infantil de México

Print version ISSN 1665-1146

Bol. Med. Hosp. Infant. Mex. vol.77 n.1 México Jan./Feb. 2020  Epub Feb 25, 2021 

Carta al editor

Zika and spontaneous abortion

Zika y aborto espontáneo

Beuy Joob1  * 

Viroj Wiwanitkit2 

1Instalaciones Sanitarias, Medical Academic Center, Bangkok, Tailandia

2Dr. DY Patil University, Pune, India

Dear Editor,

We read the publication on “Zika as a cause of spontaneous abortion in endemic areas” with a great interest1. Rivadeneyra-Espinar et al.1 concluded that “Zika infection during pregnancy must be suspected and diagnosed promptly to offer comprehensive care. The loss of conception in these patients has been documented with results of chorionic villus biopsies, finding Zika virus (ZIKV) RNA and suggesting spontaneous abortion early during viremia”1. In the present report, Rivadeneyra-Espinar et al.1 reported a case, which is concordant with another recent report by Goncé et al.2 We would like to share some ideas with this case report.

First, ZIKV infection is endemic in several areas of the world and most of the cases are asymptomatic3. Focusing on the pregnant subject, the infection can occur and might or might not affect the pregnancy outcome and infant health. The persistence of the virus in the placental tissue is possible but does not confirm the relationship between viral infection and abortion or fetal pathology or infantile health problems4. In tropical Southeast Asia, Zika is also an endemic disease and there are many infected pregnant subjects. However, to the extent of our knowledge, no studies on the intrapartum ZIKV infection related to abortion in Southeast Asia have been reported5. In an area with high rate of ZIKV immunoreactivity, such as Cambodia6, no reports have been published on the congenital ZIKV syndrome or spontaneous abortion in pregnant women. Indeed, there are no previous studies on testing for acute or recent infections with ZIKV among women who have had spontaneous abortions. The exact pathological relationship between the presence of ZIKV in the chorionic villi and pregnancy outcome should be further researched.


1. Rivadeneyra-Espinar PG, Venegas-Esquivel GA, Díaz-Espinoza CM, Pérez-Robles VM, González-Fernández MI, Sesma-Medrano E. Zika as a cause of spontaneous abortion in endemic areas. Bol Med Hosp Infant Mex. 2019;76:193-7. [ Links ]

2. GoncéA, Martínez MJ, Marbán-Castro E, Saco A, Soler A, Alvarez-Mora MI, et al. Spontaneous abortion associated with zika virus infection and persistent viremia. Emerg Infect Dis. 2018;24:933-5. [ Links ]

3. Wiwanitkit S, Wiwanitkit V. Afebrile, asymptomatic and non-thrombocytopenic zika virus infection:don't miss it!Asian Pac J Trop Med. 2016;9:513. [ Links ]

4. Santos GR, Pinto CA, Prudente RC, Bevilacqua EM, Witkin SS, Passos SD, et al. Case report:histopathologic changes in placental tissue associated with vertical transmission of zika virus. Int J Gynecol Pathol. 2019. DOI:10.1097/PGP.0000000000000586. [ Links ]

5. Wiwanitkit V. The current status of zika virus in Southeast Asia. Epidemiol Health. 2016;38:e2016026. [ Links ]

6. San K, Rajadhan V. Seroprevalence of zika virus in Cambodia:a preliminary report. Adv Lab Med Int. 2016;6:37-40. [ Links ]

Received: July 20, 2019; Accepted: October 24, 2019

* Correspondencia: Beuy Joob E-mail:

Conflicts of interest

The authors declare that they have no conflicts of interest.

Creative Commons License Instituto Nacional de Cardiología Ignacio Chávez. Published by Permanyer. This is an open ccess article under the CC BY-NC-ND license