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TIP. Revista especializada en ciencias químico-biológicas
versión impresa ISSN 1405-888X
TIP vol.9 no.1 Ciudad de México jun. 2006
Artículos de revisión
Consecuencias fisiológicas de la oxidación de proteínas por carbonilación en diversos sistemas biológicos
Psycological consequenses of protein oxidation by carbonylation in different biological models
1Lab. de Microbiología y Genética Molecular, Depto. de Biología Moleculary Biotecnología, Instituto de Investigaciones Biomédicas, UNAM. СР. 04510, México, D.F.
El metabolismo celular aerobico, al utilizar dioxígeno como último aceptor de electrones en la cadena respiratoria causa inevitablemente la producción de Especies Reactivas de Oxígeno (EROs) que oxidan cualquier macromolécula a su alcance (DNA, lípidos y proteínas). La investigación de los mecanismos de oxidación de proteínas se ha intensificado en los últimos 20 años debido a la creciente evidencia que ha correlacionado procesos como el envejecimiento y diversas patologías humanas con el aumento de la oxidación proteica. Las proteínas sufren varios tipos de oxidación; una de ellas, la formación de grupos carbonilo, ha sido utilizada metodológicamente para evaluar el grado de daño oxidativo en diferentes sistemas biológicos. A pesar de que se desconocen los mecanismos que vinculan oxidación proteica y procesos como proteólisis, apoptosis y reproducción nos encontramos cerca de descubrir el papel de la oxidación proteica en la fisiología celular.
Palabras Clave: Envejecimiento; Especies Reactivas de Oxígeno; estrés oxidativo; oxidación; proteólisis
Production of Reactive Oxygen Species (ROS) is an unavoidable consequence of the aerobic metabolism. Due to the accumulating experimental data relating protein oxidation to cell processes such as ageing and diverse human diseases, research in this area has been greatly increased. Proteins undergo different types of oxidative modifications, in particular, the formation of carbonyl groups, has been extensively used in the studies focused on the determination of the extent of protein damage. Despite the fact that the mechanisms linking protein oxidation and cellular processes such as proteólisis, apoptosis or reproduction have yet to be elucidated, we are close to understand the role of protein oxidation in cell physiology.
Key Words: Ageing; Reactive Oxygen Species; oxidative stress; oxidation; proteolisis
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Recibido: 16 de Mayo de 2006; Aprobado: 20 de Junio de 2006
Este es un artículo publicado en acceso abierto bajo una licencia Creative Commons
