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TIP. Revista especializada en ciencias químico-biológicas

versão impressa ISSN 1405-888X

TIP vol.8 no.2 México Dez. 2005

 

Artículos de revisión

La respuesta SOS en Escherichia coli

The SOS response of Escherichia coli

Jorge Serment-Guerrero1  * 

Matilde Breña-Valle1 

Javier Espinosa-Aguirre2 

1Lab. de Genética Microbiana, Depto. de Biología, Instituto Nacional de Investigaciones Nucleares. Carretera México-Toluca s/n, La Marquesa, Ocoyoacac, C.P. 52750. Apdo. Postal 18-1027, C.P. 11801, México, D.F.

2Depto. de Medicina Genómica y Toxicologia Ambiental, Instituto de Investigaciones Biomédicas, UNAM. Apdo. Postal 70228, C.P. 04510, México, D.F.


Resumen

Todos los organismos están expuestos a sufrir el ataque de diversos agentes que pueden alterar la estructura química básica de su material genético, como la luz ultravioleta, metabolitos como las aflatoxinas que producen los hongos, o incluso especies reactivas de oxígeno que se generan como producto de la respiración. Para contrarrestar tal efecto a lo largo de la evolución se han desarrollado y seleccionado diferentes estrategias o mecanismos que le permiten sobreponerse a dichas eventualidades. Dentro de éstas se encuentra la respuesta SOS, durante la cual se incrementa la expresión de un grupo de genes cuya función es la de reparar el daño en el DNA y conferir a la célula más oportunidades de sobreponerse y sobrevivir en condiciones de estrés1.

Palabras Clave: lexA; recA; reparación de DNA; respuesta SOS

Abstract

Living organisms are continously exposed to genetic damage caused by a wide diversity of agents, either external, such as radiations and different types of biomolecules, or internal, such as free radicals and reactive oxigen species generated during oxidative metabolism. DNA damage may in turn lead to mutations and cellular or oganismic death. Therefore, to cope with such effects and in order to minimize risks, different strategies have evolved in time. Among those strategies, there is the bacterial SOS response, a group genes related to repair and damage tolerance mechanisms and whose expression rises upon DNA damage. As a result, chances of cell recovery and bacterial survival to stress have considerably increased.

Key words: lexA; recA; DNA repair; SOS response

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Recibido: 14 de Octubre de 2005; Aprobado: 28 de Noviembre de 2005

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