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Revista internacional de contaminación ambiental
Print version ISSN 0188-4999
Rev. Int. Contam. Ambient vol.21 n.2 Ciudad de México Apr./Jun. 2005
Artículos
EXPOSICIÓN A FTALATOS POR PROCEDIMIENTOS MÉDICOS EN VARONES RECIÉN NACIDOS
1Universidad Autónoma del Estado de México, Facultad de Medicina y Facultad de Química, Paseo Tollocan esq. Jesús Carranza y Colón, Toluca 50180 Edo. de México, México
2Instituto Nacional de Salud Pública. Av. Universidad 655, Santa María Ahuacatitlán, Cuernavaca 62508 Morelos, México
3Instituto Mexicano de Tecnología del Agua, Paseo Cuauhnáhuac 8532 Progreso, Jiutepec, Morelos, México
4Instituto Mexicano de Petróleo, Eje Lázaro Cárdenas 152 12° piso, México D.F. 07730, México
5Universidad de la Frontera, M Montt 112 Temuco, Chile
6Instituto Mexicano del Seguro Social, Josefa Ortiz de Domínguez Sur esq. Morelos Toluca 50000 Edo. de México, México
7Instituto Mexicano del Seguro Social. Centro Médico Nacional Siglo XXI, Edificio "C" 5 piso Av. Cuauhtémoc No. 330 Col. Doctores 06725, D.F. México
Aunque la exposición a plastificantes del grupo de los ftalatos es general en la población, se sospecha que algunos grupos de infantes pueden exponerse a niveles potencialmente tóxicos. Se realizó un estudio exploratorio observacional con el propósito de determinar si los plásticos empleados en procedimientos médicos invasivos exponen a los niños recién nacidos a ftalatos a niveles mayores a los observados en la población general. Se midieron las concentraciones urinarias de los metabolitos de los ftalatos más comúnmente empleados, ftalato de monometilo (FMM), ftalato de monobutilo (FMB), ftalato de monoetilhexilo (FMEH), ftalato de monoetilo (FME) y ftalato de monooctilo (FMO) en 30 recién nacidos sometidos a procedimientos de terapia intensi va neonatal y 30 niños del servicio de cunero que no recibieron ninguna intervención médica invasiva. La media del FMEH en orina de los niños sometidos a terapia intensiva neonatal fue de 46.82 μg/L y de 5.19 μg/L para los niños de cunero (p< .001). El FMEH es el metabolito primario del ftalato de di-2(etilhexilo) (FDEH), principal plastificante utilizado en la fabricación de equipos médicos. Los resultados de este estudio exploratorio muestran elevados niveles de exposición en el grupo de recién nacidos sometidos a tratamientos en terapia intensiva neonatal comparados con el grupo de recién nacidos de cunero. El significado de esta exposición en la salud de estos niños es todavía incierto.
Palabras clave: exposición a ftalatos; CPV en tratamientos médicos
Although human exposure to plasticizers such as phthalates is generalized, some infants could be exposed at potentially toxic levels. We performed an observational study to assess if infants under invasive medical procedures are more exposed to phthalates than the general population because of the plasticizers used in medical devices. Urinary metabolites concentrations of the most commonly used phthalates, monomethyl ph-thalate (MMP), monobutyl phthalate (MBP), mono2-(ethylhexyl) phthalate (MEHP), monoethyl phthalate (MEP) and monooctyl phthalate (MOP) were measured in 30 new-borns under intensive therapy and 30 newborns from the normal maternity room. Aver-age urine MEHP concentration was 46.82 μg/L for newborns under intensive therapy and 5.19 μg/L for children in maternity room (p <0.001). MEHP is the primary metabolite of di-2(ethylhexyl) phthalate (DEHP), the main plasticizer used in medical devices. Results from this exploratory study show higher exposure levels in the group of newborns under neonatal intensive therapy as compared to newborns in maternity room. The health significance of this exposure remains uncertain.
Keywords: phthalate exposure; PVC in medical treatment
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Recibido: Agosto de 2004; Aprobado: Enero de 2005
Este es un artículo publicado en acceso abierto bajo una licencia Creative Commons
