Investigación

 

Magnetisation of red blood cells: a Brownian Dynamics Simulation

 

M.E. Canoª, R. Castañeda-Priego^b, A. Barreraª, J.C. Estradaª, P. Knauthª, and M.A. Sosa ^b

 

^a Centro Universitario de la Ciénega, Universidad de Guadalajara, Av. Universidad 1115, 47810 Ocotlan, Jal., Mexico, e-mail: eduardo.cano@cuci.udg.mx

^b División de Ciencias e Ingenierías de la Universidad de Guanajuato, Lomas del Bosque 103, Col. Lomas del Campestre, León, Gto., Mexico

 

Recibido el 27 de marzo de 2012;
Aceptado el 28 de junio de 2012

 

Abstract

A model to calculate the magnetisation of deoxyhemoglobin of human blood by means of Brownian dynamics simulations is presented. We consider a system made up of dipolar magnetic spheres, which can interact but do not overlap. Particles are exposed to external magnetic fields to compute the magnetisation curve, which exhibit a Langevin-like behaviour. The magnetic susceptibility of the erythrocytes and completely deoxygenated whole blood are x_P= 1.61 x 10^-6(SI) and χWB = —4.46 x 10^-6(SI), respectively, which are in good agreement to experimental data and theoretical calculations. Moreover, we also compute the paramagnetic component of the susceptibility of erythrocytes that in our simulations normal blood from beta thalassemia major samples could be differentiated.

Keywords: Blood; magnetisation; brownian-dynamic; susceptibility.

 

PACS: 75.Mm; 81.Ip

 

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Acknowledgement

This work was partially supported by, CONACYT (grants "APOY-COMPL-2009: 118168", 61418/2007, 102339/2008).

 

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