Purpose:

To compare the correlation between perfusion density and ganglion cell layer thickness in non-diabetic subjects and diabetics without retinopathy.

Methods:

Non-experimental, retrospective, comparative cross-sectional study in subjects without diabetes (group 1) and diabetics without retinopathy (group 2) evaluated with optical coherence tomography and optical coherence tomography angiography (Cirrus with Angioplex). We compared perfusion density between groups by quadrants (3 × 3 mm map), ganglion cell layer thickness by sectors (Mann Whitney’s U) and the correlation between variables within groups (Spearman’s Rho).

Results:

Thirty-four subjects in group 1, 38 in group 2. Inner, total, superior and nasal perfusion densities were lower in group 2 (p < 0.05); ganglion cell layer thickness did not differ between groups in any sector. There were weak correlations between inner and total perfusion densities and ganglion cell layer thicknesses in group 1; in group 2 there were weak correlations between inferior quadrant perfusion and ganglion cell layer thickness in the inferior and inferior temporal sectors, where perfusion density did not differ from group 1.

Conclusions:

The correlation between perfusion density and ganglion cell layer thickness is weak in non-diabetic subjects; diabetics without retinopathy show no correlation, observing only a lower perfusion density.

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