SciELO - Scientific Electronic Library Online

vol.65 issue2Epidemiological, clinical and diagnostic characterization of children with eosinophilic gastroenteropathy. A retrospective study of three high complexity health institutionsCommon variable immunodeficiency and its association with memory B-cell defects author indexsubject indexsearch form
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • Have no similar articlesSimilars in SciELO


Revista alergia México

On-line version ISSN 2448-9190


RICO-ROSILLO, María Guadalupe  and  VEGA-ROBLEDO, Gloria Bertha. Sleep and immune system. Rev. alerg. Méx. [online]. 2018, vol.65, n.2, pp.160-170. ISSN 2448-9190.

Sleep is a process that occupies one third part of the life of the human being, and it is essential in order for the individual to be able to maintain body homeostasis. It emerges as an important regulator of the immune system since, during sleep, the necessary functions to maintain its balance are carried out. On the other hand, decreased sleep has deleterious effects that alter the metabolism and produce an increase in the secretion of C-reactive protein, interleukin (IL)-6 and tumor necrosis factor (TNF). These cytokines activate NF-κB; therefore, sleep disturbance can be a risk factor for the development of chronic inflammatory and metabolic diseases. Pro-inflammatory cytokines IL-1, IL-6 and TNF increase non-rapid eye movement sleep, whereas anti-inflammatory cytokines such as IL-4 and IL-10 decrease it. Sleep can modify the immune system function by inducing changes in the hypothalamus-pituitary-adrenal axis and the sympathetic nervous system. In turn, the circadian rhythm of hormones such as cortisol and adrenaline, which have a nocturnal decrease, favors different activities of the immune system. The purpose of the present review is to address different aspects of sleep and their relationship with the immune system.

Keywords : Sleep; Sleep deprivation; Cytokines; Immune system; Inflammation.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )