Abstract

LOPEZ-ROCHA, Eunice et al. Angioedema as initial manifestation of hypogammaglobulinemia. Rev. alerg. Méx. [online]. 2017, vol.64, n.2, pp.228-234. ISSN 2448-9190.  https://doi.org/10.29262/ram.v64i2.187.

Common variable immunodeficiency is characterized by hypogammaglobulinemia and the inability to respond to vaccines. Patients mostly manifest infections, however only less than 5 % have pathological conditions as autoimmunity, granulomatous inflammation, and splenomegaly or lymphoproliferative disease among others, without showing infections. We report the case of a woman who debuted with localized cutaneous affection, facial angioedema, without other early symptoms. After diagnosis splenomegaly and bronchiectasis were documented. Angioedema and bronchiectasis responded with IVIG replacement. We also review the dermatological manifestations associated with CVID.

Keywords : Common variable immunodeficiency; Angioedema; Skin diseases; Primary immunodeficiency diseases in adults; Intravenous immunoglobulin.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )