Resumen

LOPEZ-GARCIA, RA  y  PENA-OLVERA, S.. Tranexamic acid neurotoxicity in pediatric renal transplantation: case report. Anest. Méx. [online]. 2019, vol.31, n.2, pp.74-83. ISSN 2448-8771.

Pediatric kidney transplantation has become the primary method of treating in children with final stage kidney disease, with 90% survival rate. Commonly, this surgery is not associated with bleeding disorders intraoperative and when this occurs; It increases postoperative morbidity and mortality. Clinical case: An Eight year old girl with chronic kidney disease stage V, due to tobulointerstitial disease, was scheduled for kidney transplantatio from a related living donor. During the surgical procedure she presented an injury in the kidney vein and renal artery, this caused an increase in circulating blood volume during severe hemorrhage; it required a masive transfusión protocol with blood products and hemodynamic stabilization with norepinephrine. Tranexamic acid was administered under a hyperfibrinolysis condition, verified by thromboelatografhy. It resulted in a reduced postoperative bleeding and the need for more blood products, however, there were side effects with seizures, attributed to an acute ischemic stroke reported by a tomography.

Palabras llave : Neurotoxicity; seizures; tranexamic acid; kidney transplantation and anesthesia.

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