Resumo

CABANAS-ROMERO, Pablo Vladimir  e  HUERTA-SAQUERO, Alejandro. Nanomáquinas biológicas: los sistemas de secreción bacterianos. Mundo nano [online]. 2014, vol.7, n.13, pp.28-36.  Epub 11-Jun-2021. ISSN 2448-5691.

Bacterial secretion systems are specialized nanomachines for delivery of proteins and other biological molecules outside the cell, allowing bacteria interact with their environment as well as with other organisms sharing their habitat, particularly those bacteria which have a close relationship with eukaryotic cells. This relationship can be symbiotic, i.e., one in which both organisms derive benefit, or parasitism or host-pathogen interactions, where bacteria affect the normal function of the host cell or whole organism which infects. To date there are seven secretion systems described. Gram-negative bacteria possess the type III secretion system (T3SS), which enables translocation of effector proteins into enterocyte cell (eukaryotic). Genes encoding proteins that integrate the T3SS are found in pathogenicity islands, whose knowledge about their composition, organization and gene expression regulation allows us to use it as vehicles for protein delivery in therapies targeting specific cells.

Palavras-chave : secretion systems; bacteria; inyectisomes; pathogenesis; symbiosis; bacteria-eukaryotic cell interaction.

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