Resumen

ODDONE, Natalia et al. De las nanobiomoléculas a la nanobiología y nanomedicina. Mundo nano [online]. 2013, vol.6, n.10, pp.45-62.  Epub 23-Jun-2021. ISSN 2448-5691.  https://doi.org/10.22201/ceiich.24485691e.2013.10.50964.

We are nowadays in a new stage in which biomedicine searches the ways to improve diagnosis and therapy of several diseases by using novel nanodevices. Polymeric micelles, liposomes, dendrimers, biodegradable nanoparticles and others are examples of nanoparticulate materials researched in laboratories, undergoing preclinical development, or already used in the clinic. At present, we have numerous nanoestructured systems with multiple potential applications in the biomedical area. Nevertheless, in spite of the fact that in many cases physicochemical characterizations of the mentioned nanosystems were carried out, their interactions with the biological systems or the nanobiomolecules that compose these systems were not studied.

In this article, we show the research performed in our laboratory. First, we describe studies we have carried out studying different nanobiomolecules. By these experiments we are trying to understand signaling and regulation of biological processes such as protein synthesis in the nervous system or RNA synthesis in the cellular nucleus. Second, we describe experiments we are performing using dendrimers and studying their possible applications to treat diseases such as premature labor, cancer or diabetes. Finally, we briefly describe atomic force microscopy applications in biological and biomedical sciences and give a concrete example of our work.

Palabras llave : nanobiomolecules; nanomedicine; dendrimers; atomic force microscopy.

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