Abstract

SORIA-LARA, Dulce María; GAITAN-VELEZ, Brayan Vladimir; JIMENEZ-ISLAS, Hugo  and  MIRANDA-LOPEZ, Rita. El Sistema de Endocannabinoides como regulador de la lipogénesis y su posible modulación por la Mangiferina. Rev. biomédica [online]. 2019, vol.30, n.2, pp.83-102.  Epub Sep 06, 2019. ISSN 2007-8447.  https://doi.org/10.32776/revbiomed.v30i2.638.

Currently, the participation of the endocannabinoid system in metabolic regulation is undeniable; because its hyperactivation has been related to several pathologies such as obesity, diabetes mellitus, retinopathy and non-alcoholic fatty liver, and others. These pathologies are related through alterations in lipid metabolism, e.g. over stimulation of fatty acid synthesis, beta-oxidation decrease, hyperglycemia increase, all these changes are caused by increase in gluconeogenesis, as well as glycolysis, processes in which the SEC has been described as a main character. On the other hand, some phytochemicals such as mangiferin (MGF) have shown their pharmacological effects on lipid metabolism, as well as glycemic control. So far, the effect of mangiferin on cannabinoid receptors is unknown. In this review, we try to demonstrate how mangiferin and these receptors participate in the opposite manner in the adaptation of lipid metabolism in many organs like as liver, tissue adipose and SN (nervous system). In addition, we suggest, based on the published information to until now, a relationship between the MGF´s effect on the SEC.

Keywords : lipogenesis; mangiferin; endocannabinoid system; cannabinoids receptor.

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