Resumen

PEREZ-ALVARADO, Joaquín  y  MORENO-ORTIZ, José Miguel. piRNAs a new biomarker field in cancer. Rev. biomédica [online]. 2017, vol.28, n.2, pp.99-104. ISSN 2007-8447.  https://doi.org/10.32776/revbiomed.v28i2.560.

The piRNAs are sequences from 24 to 32 nucleotides associated with PIWI proteins from the Argonauta family, which possesses endonuclease holdings. They are synthesized from repetitive intergenic regions and their main function is the silencing of transposons, however, it has been found that its lack of control is associated with the development of various types of cancer. Several piRNAs have been associated as biomarkers of tumor development, however, It has not been studied in all types of cancer, recent investigations show that breast and gastric cancer are on top of the list with more publications related with piRNAs. Therefore, the present review focuses on knowing the most relevant piRNAs in specific types of cancer, in order to promote their analysis in the poorly studied cancer or that predominate epidemiologically in certain populations.

Palabras llave : piRNA; cancer; biomarkers.

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