Resumo

PEREZ-VIELMA, Nadia Mabel et al. Food Craving in Obese Subjects: Its Correlation with Atherogenic Index and Feeding Behavior-Related Gene Expression. Acta de investigación psicol [online]. 2021, vol.11, n.3, pp.5-16.  Epub 14-Mar-2022. ISSN 2007-4719.  https://doi.org/10.22201/fpsi.20074719e.2021.3.388.

Obesity is influenced by environmental, behavioral, and genetic factors; particularly genes related to the regulation of lipids and addictive behavior. Food craving (FC) is a physiological and behavioral response that triggers the intense desire to ingest food, particularly food with high energy, fat, and/or sweet content. Objective: To evaluate the relationship between the prevalence of FC in obese subjects and blood lipids as well as to determine the transcriptional modulation of CART, DRD2, and FTO. Method: Transverse, comparative, and randomized study including 21 obese participants (BMI, ≥ 30 kg/m2] and 20 normal weight participants (BMI, ≤ 25 kg/m2). We determined CART, DRD2, and FTO expressions; evaluated blood lipid levels; and obtained trait scores on the Food Craving Questionnaire-Trait, a multifactorial instrument validated for the Mexican population. Results: The DRD2 expression was significantly increased (p = 0.027) and the CART expression was significantly decreased (p = 0.001) in obese participants compared with normal weight participants. The FTO expression did not show significant differences. Food Craving Questionnaire-Trait showed scores of ≥ 72 in obese participants. Conclusions: Linear regression model analysis showed that FC is a predictor of atherogenic index (ATH), independently of BMI, and of the gene expression modulation of CART and DRD2.

Palavras-chave : Atherogenic index; Blood lipids; Food craving; Gene expression; Observational.

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