Background:

The aim of the present work was to present three clinical cases with uncommon presentations of metastatic kidney cancer.

Clinical cases:

The first case was that of a woman that presented with metastasis to the thyroid gland after thyroidectomy. The rest of the extension studies were negative, and she did not require adjuvant treatment. The second case was a woman that came to the emergency department due to urinary retention secondary to urethral metastasis from a kidney tumor, with no metastases at other levels. The third case was a man that presented with recurrence of papillary renal cell carcinoma in the bladder mucosa associated with lung metastases.

Discussion:

Thirty-four percent of metastases to the thyroid gland have a renal origin. The urethra is an uncommon site for metastasis. In general, bladder metastases from renal carcinoma have a poor prognosis, with only 56 cases described in the literature. The treatment of choice for resectable lesions is surgical extirpation, and anti-angiogenic therapy is reserved for nonresectable lesions.

Conclusions:

The thyroid gland, bladder, and urethra are uncommon sites of metastases from kidney cancer. They tend to indicate advanced disease stages and treatment is surgical extirpation in cases of resectable lesions.

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