SciELO - Scientific Electronic Library Online

vol.5 issue2Monosporic strains of Metarhizium anisopliae and its pathogenicity to Galleria mellonella in Tabasco, MexicoProductive and reproductive performance at farrowing and at weaning of sows of seven genetic lines author indexsubject indexsearch form
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • Have no similar articlesSimilars in SciELO


Revista mexicana de ciencias pecuarias

On-line version ISSN 2448-6698Print version ISSN 2007-1124


SANTOS ECHEVERRIA, Rubén et al. Luteinizing hormone and ovarian activity in response to kisspeptin-10 and its association with IGF-1 and leptin in prepubertal heifers. Rev. mex. de cienc. pecuarias [online]. 2014, vol.5, n.2, pp.181-200. ISSN 2448-6698.

We evaluated the effect of kisspeptin-10 (Kiss-10) administered repeatedly on the release of LH and ovarian activity in prepubertal heifers. We also assessed the association of serum IGF-1 and leptin with these effects. Fourteen Holstein or Brown Swiss by Zebu female calves (11.2 ± 0.2 mo old, 187.4 ± 6.3 kg) were randomly assigned to receive every 2 h for three days an i.v. application of Kiss-10 (Kisspeptin-10; 5 pg/kg of body weight, n= 7) or saline solution (control, n= 7). Blood was collected every 15 min for 0-6, 24-30 and 72-78 h, and every 2 h until 84 h. Each application of Kiss-10 was followed by an increase of LH whose magnitude (area under the curve) decreased (P<0.05) over time. Kiss-10 induced a preovulatory surge of LH and corpus luteum formation in 28.5 % of the calves. Ovulating calves had the highest (P<0.05) serum concentrations of 1Gf-1 and the lowest (P<0.05) leptin. During 63 post-treatment days, no changes were detected in follicular waves attributable to treatments (P>0.05) and heifers did not show cyclic ovarian activity. The conclusion is that Kiss-10 given repeatedly to prepubertal heifers is sufficient to evoke consistent increases of LH, to induce ovulation and luteal activity in animals with high IGF-1 and low leptin in peripheral blood but it is insufficient to establish regular estrous cyclicity.

Keywords : Prepubertal heifers; Kisspeptin; IGF-1; Leptin; Luteinizing hormone.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License