Abstract

NARASIMHA RAJU, Pericherla V. S. et al. Synthesis of New Hispolon Derived Pyrazole Sulfonamides for Possible Antitubercular and Antimicrobial Agents. J. Mex. Chem. Soc [online]. 2021, vol.65, n.2, pp.237-246.  Epub June 04, 2021. ISSN 1870-249X.  https://doi.org/10.29356/jmcs.v65i2.1458.

A series of 10 new hispolonpyrazole sulfonamides were designed and synthesized using hispolons and 4-sulfonamide phenylhydrazine hydrochloride with better yields. The synthesized pyrazole sulfonamides were screened for anti-TB, anti-bacterial, and anti-fungal activities to compare the role sulfonamide moiety. Among them, 3a and 3b showed selective potent anti-tubercular nature (MIC 6.25µg/mL). Further, the antimicrobial studies of the compounds showed only compound 3b with a good inhibition zone on Staphylococcus aureus among other bacteria and fungi studied.

Keywords : Hispolon; sulfonamides; hispolon pyrazole; antimicrobial activity; pyrazole sulfonamides; anti TB.

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