Resumen

TUNC, Turgay et al. DNA Binding and Cleavage Activity of Three New Copper (II) Complexes of Chiral N-salicyl-β-amino Alcohol Schiff Bases. J. Mex. Chem. Soc [online]. 2018, vol.62, n.3, pp.51-66.  Epub 02-Jul-2020. ISSN 1870-249X.  https://doi.org/10.29356/jmcs.v62i3.424.

Three new copper(II) complexes (1-3) with general formula [Cu(HL)CH3COO] of N-salicyl-β-amino alcohol Schiff bases containing, (S)-(+)-phenyl glycinol, (1S, 2R)-2-amino-1, 2-diphenylethanol and 1, 1, 3-triphenyl-(R)-(+)-2-amino propanol, were synthesized. Their structures were characterized by FTIR, LCMS, magnetic moment, molar conductance and elemental analysis data. DFT calculations proposed distorted square planar geometries for the complexes. The calculated IR spectra are in good agreement with the experimental IR spectra, confirming the proposed structures. Their interactions with calf thymus DNA were investigated and their binding constants Kb were found. Gel electrophoresis reveals that all complexes display significant nuclease activity against supercoiled pentry/d-topo plasmid DNA.

Palabras llave : Copper (II) complexes; DFT calculations; DNA binding; DNA cleavage; Schiff base complexes.

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