Abstract

SHUNMUGA PRIYA, Ramasamy; UMA MAHESWARI, Govindhasamay; DEEPA, Manicam  and  KARTHIKEYAN, Parasuraman. Imidazolium Supported Iron-chloroglycine Complex, a Good Turnover Recyclable Catalyst for the Solvent Free Synthesis of 3, 4-dihydropyrimidin-2(1H)-ones - promoted by Ultrasound Irradiation. J. Mex. Chem. Soc [online]. 2018, vol.62, n.3, pp.29-38.  Epub July 02, 2020. ISSN 1870-249X.  https://doi.org/10.29356/jmcs.v62i3.779.

A novel large band gap 1-glycyl-3-methyl imidazolium chloride-iron (III) complex [[Gmim]Cl-Fe(III)] was found to be a heterogeneous catalyst for an efficient and solvent free synthesis of 3,4-dihydropyrimidin-2(1H)-ones by condensation of substituted aldehydes, ethyl acetoacetate and urea (or) thiourea with tremendous yields in high turnover number (4.1X102 to 18.8X102) at ambient temperature using ultrasound irradiation as the activation mode of reaction. This operation formulates very interesting, ecological perspective due to simple reaction condition, isolation and purification of products. In addition, this methodology offers a competitive recyclability of the catalyst without a significant loss of its catalytic activity and could be readily reused, thus making this protocol more environmentally acceptable whilst no catalyst leaching was observed.

Keywords : Iron(III) complex; Multi-component reactions; Ultrasonication; Ionic liquid; Green approach.

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