Resumen

VILA-LUNA, María Leonor; MOO-PUC, Rosa Esther; TORRES-TAPIA, Luis Wiliunfo  y  PERAZA-SANCHEZ, Sergio Rubén. Cytotoxic Activity of Casearborin C Isolated from Casearia corymbosa. J. Mex. Chem. Soc [online]. 2018, vol.62, n.3, pp.24-28.  Epub 02-Jul-2020. ISSN 1870-249X.  https://doi.org/10.29356/jmcs.v62i3.370.

Casearborin c (1), syringic acid (2), ent-3β-hydroxy-(-)-13-epi-manoyl oxide (3), ent-(-)-13-epi-manoyl oxide (4), ent-(-)-kaur-16-en-19-oic acid (5), and γ-sitosterol (6) were isolated from Casearia corymbosa stem bark. Only casearborin c showed cytotoxic activity on HeLa and SiHa cancer cell lines. This work contributes to the description of three compounds (1-3) newly isolated from C. corymbosa and highlights that casearborin c, a clerodane-type diterpene, is responsible for the cytotoxic activity shown in the original methanol extract of this species.

Palabras llave : Salicaceae; Casearia corymbosa; cytotoxic activity; diterpenes; clerodanes; casearborin c.

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