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Journal of the Mexican Chemical Society
versión impresa ISSN 1870-249X
Resumen
JAVAHERSHENAS, Ramin y KHALAFY, Jabbar. One-pot, three-component Synthesis of pyrrolo[2,3-d]pyrimidine Derivatives. J. Mex. Chem. Soc [online]. 2018, vol.62, n.1, 00009. ISSN 1870-249X. https://doi.org/10.29356/jmcs.v62i1.340.
A green approach for the synthesis of polyfunctionalized pyrrolo[2,3-d]pyrimidine derivatives was successfully achieved by a one-pot three-component reaction of arylglyoxals, 6-amino-1,3-dimethyluracil and barbituric acid derivatives in the presence of tetra-n-butylammonium bromide (TBAB) (5 mol%) as the catalyst in ethanol at 50 °C. This protocol has many advantages such as high yields (73-95%), green and simple procedure, short reaction times, easy work-up, mild reaction conditions and general applicability.
Palabras llave : 6-Amino-1,3-dimethyluracil; arylglyoxals; barbituric acid derivatives; TBAB; pyrrolo[2,3-d]pyrimidines; one-pot; multicomponent reactions.