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Journal of the Mexican Chemical Society

versión impresa ISSN 1870-249X

Resumen

ASHOK, Dongamanti; ZIAUDDIN, Mohammad; LAKSHMI, Bommidi Vijaya  y  SARASIJA, Madderla. Synthesis of (E)-(4-(Aryl)phenyl)(3-(2-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)vinyl)benzofuran-2-yl)methanones by Claisen Schmidt-Suzuki Cross Coupling and their Antibacterial and Antifungal Activity. J. Mex. Chem. Soc [online]. 2017, vol.61, n.3, pp.167-176. ISSN 1870-249X.

A series of ten novel (E)-(4-(aryl)phenyl)(3-(2-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)vinyl)benzofuran-2-yl)methanones (7a-j) derivatives were prepared by traditional Claisen-Schmidt and Suzuki cross-coupling reaction under conventional and microwave irradiation conditions. The structures of all the newly synthesized compounds were established on the basis of FTIR, 1H NMR, 13C NMR, mass spectral data and elemental analysis. The products were assayed for their in vitro antibacterial activity against different types of bacterial strains. Further the antifungal activity was examined by inhibitory action against three fungal strains such as Aspergillus niger, Aspergillus flavus and Fusarium oxysporum.

Palabras clave : Aromatic boronic acid; Antimicrobial activity; Microwave irradiation; Claisen-Schimdt; Suzuki cross-coupling reaction.

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