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Journal of the Mexican Chemical Society

versión impresa ISSN 1870-249X

Resumen

EKENGARD, Erik et al. A pyrazine amide - 4-aminoquinoline hybrid and its rhodium and iridium pentamethylcyclopentadienyl complexes; evaluation of anti-mycobacterial and anti-plasmodial activities. J. Mex. Chem. Soc [online]. 2017, vol.61, n.2, pp.158-166. ISSN 1870-249X.

The synthesis and characterization of N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyrazine-2-carboxamide (L), an aminoquinoline - pyrazinamide hybrid, and the complexes (N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyrazine-2-carboxamide)(cyclopentadienyl)chlorido-rhodium or iridium hexafluorophosphate ([M(L)(Cp*)Cl]PF6; M = Rh, Ir) and the corresponding chlorido salts ([M(L)(Cp*)Cl]Cl; M = Rh, Ir) are described. The ligand and the hexafluorophosphate salts of the metal complexes have been evaluated for anti-plasmodial and anti-mycobacterial activity. The rhodium and the iridium complexes were significantly more active against M. tuberculosis than the free ligand. The crystallographically determined molecular structures of complexes (N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyrazine-2-carboxamide)(cyclopentadienyl)chlororhodium hexafluoro-phosphate and (N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyrazine-2-carboxamide)(cyclopentadienyl)chloro-iridium chloride are presented.

Palabras clave : Malaria; tuberculosis; half-sandwich; organometallic; chloroquine; pyrazinamide.

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