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Journal of the Mexican Chemical Society

versión impresa ISSN 1870-249X


VISBAL, Gonzalo et al. Metal-azasterol complexes: Synthesis, characterization, interaction studies with DNA and TrxR and Biological Evaluation. J. Mex. Chem. Soc [online]. 2017, vol.61, n.2, pp.146-157. ISSN 1870-249X.

A new azasterol 22-hydrazine-imidazolin-2-yl-chol-5-ene-3β-ol (AH3) and their derivatives [Au(AH3)Cl] (1) and [Cu(AH3)2(H2O)2](NO3)2 (2) were synthesized and characterized by a combination of elemental analyses, 1H and 13C -NMR, UV-vis and infrared spectroscopies. The interactions with two targets DNA and TrxR were investigated. The results from these studies suggested that these metal-azasterol complexes interact with DNA most probably by covalent binding. Complex 1 showed also the ability to strongly inhibit TrxR. Additionally, their activities against yeast cells of Sporothrix spp. were evaluated; finding that complex 1 was the most active, even better than itraconazole.

Palabras llave : Azasterol; gold; copper; DNA; thiorredoxin reductase; Sporothrix spp.

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