Abstract

ROSAS-VALDEZ, María Elena et al. Synthesis and Modification of the Amyloid Peptide Sequence 37-42 of Aβ42 (AβPP): Efficient Synthesis of N-methylated Peptides, Expanding the Tools for Peptide Research. J. Mex. Chem. Soc [online]. 2016, vol.60, n.3, pp.125-134. ISSN 1870-249X.

We report the synthesis and characterization of N-alkyl modified peptides by efficient coupling of N-methyl amino acids in solution phase. As a model peptide, the segment 37-42 (GGVVIA) of the Aβ-42 amyloid peptide derived from the amyloid precursor protein (Aβ-PP) was chosen. This peptide and its derivatives with N-methyl groups on Val40 and Ile41 residues were synthesized and characterized. Because the synthesis was performed in solution-phase, the procedure can be easily scaled up for the production of larger amounts of the peptides described in this work or any linear N-methyl peptide with potential therapeutic application.

Keywords : Amyloid; Peptides; AβPP; N-Methyl Amino Acids.

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