Abstract

HASSANKHANI, Asadollah. A Rapid, One-pot, Multi-component Route to 4,4'-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols). J. Mex. Chem. Soc [online]. 2015, vol.59, n.1, pp.1-4. ISSN 1870-249X.

A new, efficient and environmentally benign protocol for the one-pot, multicomponent synthesis of 4,4'-arylmethylene-bis(3-methyl1-phenyl-1H-pyrazol-5-ols) by condensation of aryl aldehydes, phenyl hydrazine and ethyl acetoacetate catalyzed by Ce(SO₄)₂^.4H₂O as an ecofriendly catalyst with high catalytic activity and reusability at 125 °C under solvent-free conditions is reported. The reaction proceeds to completion within 5-12 min in 81-98% yield. This new green methodology is of interest due to minimizing the cost of operational hazards and environmental pollution, its excellent yields, short reaction time and high catalyst activity and reusability.

Keywords : Ce(SO₄)₂^.4H₂O; 4,4'-arylmethylene-bis(3-methyl-1-phenyl-1H-pyrazol-5-ols); Heterogeneous Catalyst; Environmentally Friendly; Solvent-free Conditions.

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