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Journal of the Mexican Chemical Society
Print version ISSN 1870-249X
Abstract
FATIMA, Ismat et al. Synthesis of Some Novel Derivatives of 2-(9H-purin-6-ylsulfanyl) Acetohydrazide as Potential Antithyroid Agents. J. Mex. Chem. Soc [online]. 2012, vol.56, n.4, pp.362-368. ISSN 1870-249X.
Some novel derivatives of 2-(9H-Purin-6-ylsulfanyl) acetohydrazide were synthesized by reacting it with respective aldehydes in ethanol. The antithyroid effect of these compounds was ascertained in vitro by studying their complexation with iodine spectrophotometrically. In vivo, the hormonal as well as histological variations in male Wistar rats demonstrated significant antithyroid potential (p ≤ 0.05) of these compounds.
Keywords : Hyperthyroidism; Antithyroid activity; Hydrazides; In vitro activity; In vivo Activity.