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Journal of the Mexican Chemical Society

versión impresa ISSN 1870-249X


TIBHE, Gaurao D.; REYES-GONZALEZ, Miguel Ángel; CATIVIELA, Carlos  y  ORDONEZ, Mario. Microwave-assisted High Diastereoselective Synthesis of α -Aminophosphonates under Solvent and Catalyst Free-conditions. J. Mex. Chem. Soc [online]. 2012, vol.56, n.2, pp.183-187. ISSN 1870-249X.

A simple, efficient and general method has been developed for the high diastereoselective synthesis of α-aminophospho-nates through "one-pot" three-component reaction of alkyl and aryl aldehydes with (S)-α-methylbenzylamine or (S)-3,3-dimethyl-2-butylamine and dimethyl phosphite (Kabachnik-Fields reaction), which proceeds in short time using microwave irradiation under solvent and catalyst free-conditions. This method could be useful in the large-scale synthesis of α-aminophosphonates in short reaction time.

Palabras clave : Three-component Reaction; Diastereoselective Synthesis; α-aminophosphonates; Aicrowave; Green-Chemistry.

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