Abstract

ALVAREZ-PARRILLA, Emilio et al. Formation of Two 1:1 Chlorogenic Acid: β-cyclodextrin Complexes at pH 5: Spectroscopic, Thermodynamic and Voltammetric study. J. Mex. Chem. Soc [online]. 2010, vol.54, n.2, pp.103-110. ISSN 1870-249X.

Complexation of chlorogenic acid (CA) by β-cyclodextrin (β-CD) at mildly acidic pH, was studied by fluorescence spectroscopy, isothermal titration calorimetry (ITC), cyclic voltammetry (CV) and NMR spectroscopy. Thermodynamic parameters (ΔH°, ΔS° and K) determined by both fluorescence and ITC, showed that the complexation of CA by β-CD is an enthalpy-driven process. Results show that CA molecule can be complexed through both polyphenolic and quinic acid moiety, leading to the formation of two supramolecular isomers with 1:1 stoichiometry.

Keywords : β-cyclodextrin; chlorogenic acid; inclusion complexes; fluorescence; isothermal titration calorimetry (ITC); thermodynamic parameters.

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