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Journal of the Mexican Chemical Society

Print version ISSN 1870-249X


YU LIN, Hu; XIANG, Liu  and  MING, Lu. Synthesis and Biological Activity of Novel 6-Substituted Purine Derivatives. J. Mex. Chem. Soc [online]. 2010, vol.54, n.2, pp.74-78. ISSN 1870-249X.

A series of 6-substituted purines were synthesized from commercially available 2-amino-6-chloropurine with appropriate reagents, and nine new compounds 7, 8, and 11-17 have been discovered. The compounds synthesized were identified by elemental analysis, 1H NMR, as well as mass spectral data. All the title compounds were screened for their antifungal activities, under the method of the disc diffusion, using three species of fungi - Bacillus subtillis, Aspergillus niger, and Candida tropicalis- and some of the compounds showed promising activities.

Keywords : 6-Substituted purines; 2-amino-6-chloropurine; Synthesis; Antifungal Activity.

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