Journal of the Mexican Chemical Society
versión impresa ISSN 1870-249X
DIAZ-COUTINO, Francisco D. y ESCALANTE, Jaime. Efficient 'One Pot' Nitro Reduction-Protection of γ-Nitro Aliphatic Methyl Esters. J. Mex. Chem. Soc [online]. 2009, vol.53, n.3, pp. 93-95. ISSN 1870-249X.
A simple and efficient protocol has been developed for the direct conversion of γ-nitro aliphatic methyl esters to N-(tert-butoxycarbonyl)amine methyl esters using NH4+HCO2- and Pd/C in the presence of (Boc)2O. There was a significant decrease in the reaction time under these conditions, increased yields and the purity of the products using this 'one pot' procedure.
Palabras llave : 'One-pot' reaction; γ-nitro reduction; N-Boc-amino protection.